RESUMO
Regeneration and tolerance factor (RTF) is a protein with immunosuppressive activity and is normally present in the thymus and placenta. RTF was measured in the livers of patients with regenerating nodules due to alcoholic cirrhosis and hepatitis C. RTF was expressed in the regenerating nodules of 26 patients with alcoholic cirrhosis. All patients with chronic hepatitis C without cirrhosis failed to express RTF. Flow cytometry revealed upregulation of RTF on the lymphocytes from alcoholic cirrhosis and downregulation in hepatitis C disease.
Assuntos
Antígenos CD , Hepatócitos/metabolismo , Cirrose Hepática Alcoólica/imunologia , Cirrose Hepática Alcoólica/metabolismo , Proteínas da Gravidez/biossíntese , Fatores Supressores Imunológicos/biossíntese , Linfócitos T/metabolismo , ADP-Ribosil Ciclase , ADP-Ribosil Ciclase 1 , Antígenos de Diferenciação/análise , Citometria de Fluxo , Antígenos HLA-DR/análise , Hepatite C Crônica/imunologia , Hepatite C Crônica/metabolismo , Hepatócitos/química , Humanos , Imuno-Histoquímica , Glicoproteínas de Membrana , NAD+ Nucleosidase/análise , Proteínas da Gravidez/análise , Fatores Supressores Imunológicos/análise , Linfócitos T/químicaRESUMO
Cryptic/sporadic malaria is rare in the United States. We describe a patient who developed malaria in New York City without any known contact with, or travel to, a malaria-endemic area. The patient presented with symptoms of gastroenteritis. Later, she developed hemolysis and hepatosplenomegaly, and Plasmodium falciparum was found in blood smears. Possible sources of malaria could be an indigenous infected mosquito or a transported infected mosquito from a local international airport.
