RESUMO
INTRODUCTION: since the 1990s, the literature has described cases of glioblastoma metastases with the development of foci located at a distance from the primary tumor. However, the pathogenesis of this process remains unclear until the end. This focus is believed to result, on the one hand, from tumor metastasis from the primary site and, on the other hand, from multifocal growth. This article presents a literature review and a description of clinical observations of patients with glioblastoma metastases. MATERIAL AND METHODS: The study included 6 patients (1 female and 5 males) with brain glioblastomas who received treatment at the Burdenko Neurosurgical Institute (5 patients) and the Department of Neurosurgery of the Research Center of Neurology (1 patient) in the period from 2010 to 2014. Neurophysiological control was used if the tumor was localized near the eloquent cortical areas and pathways; 4 of 6 patients were operated on using the methods of intraoperative fluorescence diagnosis (5-ALA agent--Alasens). RESULTS: Four patients had metastases within one hemisphere, two had metastases in the contralateral hemisphere in the period of 5 to 18 months after the first operation. The primary tumor site was located near the ventricular system in two patients. In one patient, the lateral ventricle was opened during the first operation. In another patient, the prepontine cistern was opened during the first operation. In two patients, the primary tumor site was located at a distance from the lateral ventricles, however, the tumor was located near them during recurrence. Based on metabolic navigation, fluorescence of the tumor was observed in the four patients during both the first and repeated operations. CONCLUSIONS: The close relationship between primary glioblastomas and metastases and the cerebrospinal fluid circulation pathways may confirm the fact of dissemination of tumor cells with cerebrospinal fluid flow. In our opinion, there should be an increased suspicion of the possibility for metastases of glioblastomas that are closely associated with the cerebrospinal fluid circulation pathways. Metabolic navigation with 5-ALA is effective both during primary surgery in patients with glioblastomas and during resection of glioblastoma metastases.
Assuntos
Neoplasias Encefálicas/patologia , Glioblastoma/secundário , Idoso , Neoplasias Encefálicas/líquido cefalorraquidiano , Neoplasias Encefálicas/cirurgia , Movimento Celular , Feminino , Glioblastoma/líquido cefalorraquidiano , Glioblastoma/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Resultado do TratamentoRESUMO
Influence of immunomodulators with organometallic origin on sensitivity to mice toxin on CBA, C Bl/6 mice and hybrids F1 (CBA C Bl/6) has been investigated. It has been determined that used immunomodulators are the means of urgent change of sensitivity to plague intoxication (5 min after i.v. administration of immunomodulators, the sensitivity to mice toxin changes). The character of immunomodulators' influence on sensitivity to plague intoxication depends on daily time and animals' genotype.
Assuntos
Adjuvantes Imunológicos/farmacologia , Toxinas Bacterianas/farmacologia , Compostos Organometálicos/farmacologia , Yersinia pestis , Animais , Genótipo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Especificidade da EspécieAssuntos
5'-Nucleotidase/efeitos dos fármacos , Adjuvantes Imunológicos/farmacologia , Ritmo Circadiano/efeitos dos fármacos , Germânio/farmacologia , Macrófagos/efeitos dos fármacos , Compostos Organometálicos/farmacologia , 5'-Nucleotidase/análise , Animais , Líquido Ascítico/citologia , Relação Dose-Resposta a Droga , Macrófagos/enzimologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Fatores de TempoAssuntos
Germânio/farmacologia , Indutores de Interferon/farmacologia , Interferon gama/efeitos dos fármacos , Leucócitos/efeitos dos fármacos , Compostos Organometálicos/farmacologia , Células Cultivadas/efeitos dos fármacos , Células Cultivadas/imunologia , Efeito Citopatogênico Viral/efeitos dos fármacos , Relação Dose-Resposta a Droga , Enterotoxinas/farmacologia , Humanos , Interferon gama/biossíntese , Interferon gama/sangue , Leucócitos/imunologia , Staphylococcus aureus , Vírus da Estomatite Vesicular IndianaRESUMO
The influence of new synthesized fluoro-silicium-organic complexes on the virus-induced Rauscher leukosis and cell-transferred MX-11 mouse sarcoma was studied. We also studied the cytotoxic effects of these complexes in vitro in the human CaOv cells. Two complexes from seven studied were cytotoxic for CaOv cells. Five complexes from seven studied diminished the mortality of animals with MX-11 tumors on the 27-th day of observation, but the total life duration of the animals in the experimental group was the same as in controls. One complex from seven studied increased the life duration of mice with MX-11 tumors. No effects were noted in relation to mice virus-induced Rauscher leukosis.