[Toxicity and radioprotective properties of 3,4,5,6-tetrahydropyrimidine and 3,6-dihydropyrimidine derivatives]. / Toksichnost' i radiozaschitnye svoistva nekotorykh proizvodnykh 3,4,5,6-tetragidropirimidinov i 3,6-digidropirimidinov.

Acute toxicity and radioprotective properties of 16 derivatives of tetrahydro- and dihydropyrimidines were studied in experiments on mice. Hydroiodides of 4,6,6-trimethyl-3,R-2-methylthio-3,6-dihydropyrimidines were shown to be more toxic than respective hydroiodides of 4,6,6-trimethyl-3-R-2-methylthio-4-oxy-3,4,5,6-tetrahydropyrimidines. Four compounds exhibited moderate radioprotective properties.

[Toxicity and radioprotective properties of 1,3-oxazine and 1,3-thiazine derivatives]. / Toksichnost' i radiozashchitnye svoistva proizvodnykh 1,3-oksazina i 1,3-tiazina.

Toxicity and radioprotective properties of 18 derivatives of oxazine and thiazine with a varying degree of the cycle saturation were studied in experiments on mice. Monotypic regularity in variations of their toxic properties relative to the chemical structure was noted. 4,4,6-Trimethyl-2-dimethylamino-4H-1,3-oxazine exerted a pronounced radioprotective action.

[Radioprotective and toxicological properties on some 4-oxyhexa- and 1,2,3,6-tetrahydroprimidine-2-thione derivatives]. / Padiozashchitiye i toksikologicheskie svoistva nekotorykh proizvodnykh 4-oksigeksa- i 1,2,3,6-tetragidropirimidintiona-2.

Test on mice demonstrated the radio-protective activity of 12 derivatives of 4-oxyhexahydropyrimidinethione-2 and 1,2,3,6-tetrahydropyrimidinethione-2 well-marked with intraperitoneal administration 10--20 minutes prior to irradiation (1000 r, exposure dose rate--10 r/min). As a whole the tetrahydroderivates are more toxic.