RESUMO
The article presents a data on structural and functional organization of GABA-ergic system of brain and the role GABA in mechanisms of the pathologic pain.
Assuntos
Encéfalo/metabolismo , Dor/metabolismo , Receptores de GABA/metabolismo , Ácido gama-Aminobutírico/metabolismo , Animais , Encéfalo/fisiopatologia , GABAérgicos/farmacologia , HumanosRESUMO
The present investigation was undertaken in order to study the role of the antibodies to neurotransmitters of antinociceptive system in pathogenesis of neuropathic pain on models of neuropathic pain. It was shown that the development of experimental neuropathic pain syndrome is accompanied with induction of autoantibodies to CABA, serotonin, noradrenalin and dopamine. It was established that the antibodies to neurotransmitters of antinociceptive system have a pronociceptive effect.
Assuntos
Anticorpos/farmacologia , Neuralgia/tratamento farmacológico , Neurotransmissores/antagonistas & inibidores , Nociceptividade/efeitos dos fármacos , Animais , Anticorpos/imunologia , Anticorpos/uso terapêutico , Masculino , Neuralgia/etiologia , Neurotransmissores/imunologia , Ratos , Ratos WistarRESUMO
In electrophysiological and behavioral experiments on rats we studied the effects of pefloxacin, a member of fluoroquinolone family, on the nociceptive system. Intraperitoneal injection of pefloxacin (80 mg/kg) decreased the thresholds of nociceptive response to noxious stimulation in the hot-plate test. In addition, it decreased the threshold of the late component of nociceptive flexor reflex. Intrathecal application of pefloxacin in a dose of 20 microg provoked allodynia, while the higher dose of 400 microg induced behavioral pattern characteristic of central pain syndrome. It was hypothesized that pain induced by pefloxacin results from disturbances in GABAergic inhibition in the central subdivisions of the nociceptive system.
