[Contents of BDNF, miR-30a-5p and miR-122 during alcohol withdrawal syndrome]. / Uroven' BDNF, miR-30a-5p i miR-122 v syvorotke krovi v dinamike sindroma otmeny alkogolia.

Some BDNF (brain-derived neurotrophic factor)-targeted microRNAs such as miR-30a-5p associate with alcohol dependence phenomenon however their relationship with AWS is not described. We aimed to measure serum BDNF concentration and relative content of miR-30a-5p over the course of alcohol abstinence and compare obtained results with clinics of AWS. Additionally, we studied relative serum content of miR-30a-5p, a microRNA which does not target BDNF but relates to alcohol use disorder. Serum BDNF concentration increased over the course of alcohol abstinence, contrary relative content of miR-122 but not miR-30a-5p decreased. Moreover, during AWS miR-122 but miR-30a-5p negatively correlated with serum BDNF concentrations. Relative content of miR-122 negatively correlated with depression and state anxiety levels on 8th day of abstinence. According to multiple regressions on 21st day of abstinence alcohol craving and cognitive disturbances may be predictors of serum BDNF concentration, and vice versa. Thus, serum BDNF concentration and relative content of miR-122 associate with some aspects of AWS clinics and may dynamically reflect AWS severity.

Overview of the mental health research among residents of contaminated territories and Chernobyl clean up workers/"liquidators" in Belarus. / OBZOR ISSLEDOVANII V OBLASTI PSIKhIChESKOGO ZDOROV'Ia SREDI ZhITELEI ZAGRIaZNENNYKh TERRITORII I ChERNOBYL'SKIKh "LIKVIDATOROV " V RESPUBLIKE BELARUS'.

This review deals with the latest information concerning the studies of the effect of the Chernobyl accident on the mental health of different population groups of Belarus. Observed the pathogenesis of mental disorders, develop ing in individuals living in the contaminated territories. Reviewed different factors affecting the mental health of such population group as the liquidators. Disclosed is a phenomenon of squatters ("samosely") - people who vol untarily returned to their homes in the exclusion zone after the forced relocation. The data studies, including its own, mental disorders in children, exposed to radioactive exposure in different periods of development.