1.
Bioorg Med Chem Lett
; 15(1): 217-20, 2005 Jan 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15582442
RESUMO
The discovery and SAR of 2,3-diphenylpropionic acid derivatives as highly potent VLA-4 antagonists are described. One representative compound, 9cc has inhibited intercellular adhesion by a VCAM-1/VLA-4 interaction with an IC(50) of 1.7 nM, and has good pharmacokinetics and oral bioavailability.
