[Effects of arginine aspartate when administered orally, upon nitrogen balance of the rabbit, normal or treated by glucocorticoids (author's transl)]. / Effets de l'aspartate d'arginine, administré par voie orale, sur le bilan d'azote du lapin normal ou traité par l'hydrocortisone.

A nitrogen balance study is performed upon young male rabbit, non treated or treated with glucocorticoids (hydrocortisone : 15 mg a day for 18 days). Arginine aspartate, when administered daily "per os" at fast, 1 500 mg/kg for 4 days, increases strongly nitrogen retention, in non treated rabbit (p less than 0,01). During the last four days of the glucocorticoids treatment, the product (1 500 mg/kg a day) corrects the decrease (p less than 0,01) of nitrogen balance induced by hydrocortisone. Nitrogen retention appears to be more important (p less than 0,01) than the one induced by hydrocortisone alone, and returns to the non treated rabbit value. Arginine aspartate oral administration can provoke, by the way of stimulation of endogenous growth hormone secretion, a protein anticatabolic effect.

[Potentiation by clofibride of the heparin-induced clearing reaction (intravascular hydrolysis of neutral lipids), in hyperlipemic rabbits]. / Potentialisation par le clofibride de la réaction de clarification à l'héparine (hydrolyse intravasculaire des lipides neutres), chez le lapin hyperlipémique.

A 16 days clofibride treatment in hyperlipaemic rabbit (fat supply), reduces hypertriglyceridemia and hypercholesterolemia. Heparine clearing reaction, performed on the 17th day, with the daily clofibride dose ingested in one time, is increased. The exaggerated intravascular lipids hydrolysis could explain, in part, the hypolipaemic action of clofibride.

[Effect of clofibride on the lipolysis of perirenal adipose tissue in hyperlipemic rabbits]. / Actions du clofibride sur la lipolyse du tissu adipeux périrénal chez le lapin hyperlipémique.

In hyperlipaemic rabbits (fat supply), perirenal adipose tissue lipolysis does not vary with one in vitro clofibride dose. After a 16 days pretreatment, one in vitro clofibride dose reduces the basal lipolysis and the lipolytic action of synacthene, and increases the antilipolytic effect of insulin. The reduction of the lipolysis of adipose tissue could explain, in part, the hypolipaemic action of clofibride.