[Complications after laparoscopic cholecystectomy]. / Otlozhneniia posle vypolneniia laparoskopicheskoi kholetsistéktomii.

In 1780 patients the results of laparoscopic cholecystectomy (LCH) conduction for 1992-1997 period were analysed. In 1123 (63%) patients the operation was conducted for chronical and in 657 (37%)--for an acute cholecystitis. In 162 (9.1%) patients the choledocholithiasis features were revealed before the operation. In 46 (2.6%) patients the conversion to open laparotomy was accomplished. The LCH operation duration was from 35 to 190 min, (50 +/- 12) min in average. The frequency of an early complications occurrence was 8.8%, and in 18 (1.4%) patients the complications were revealed in late follow-up period. All the patients survived.

[Some aspects of reproductive function and social adaptation after comprehensive therapy of childhood Hodgkin's disease]. / Nekotorye aspekty reproduktivnoi funktsii i sotsial'noi adaptatsii posle kompleksnogo lecheniia limfogranulematoza u detei.

An analysis of the data available on the reproductive status and social adjustment of 443 children who received three modalities of complex treatment for Hodgkin's disease in 1976-1994 established no impairment of reproductive function or its formation, although full therapeutic effect had been achieved. Nor were their intelligence or professional and social function affected in any way.

[Cardioxane in pediatric oncohematology]. / Kardioksan v detskoi onkogematologii.

The tolerance of cardioxan (JCRF-187, dexrazoxan), an ethylenediamine tetra-acetic acid analog and a Chiron Company product, administered to pediatric oncohematological patients, is discussed. The drug was used in 37 cases of acute lymphoblastic and non-lymphoblastic leukemia, non-Hodgkin's lymphoma and Hodgkin's disease treated by polychemotherapy including anthracycline antibiotics administration. No untoward side-effects or inhibition of the therapeutic effect were observed.

[Social and medical aspects of multimodality therapy for lymphogranulomatosis in children]. / Sotsial'nye i meditsinskie aspekty kompleksnoi terapii limfogranulomatoza u detei.

The high efficiency of treatment of lymphogranulomatosis in children by the currently available protocols determines the necessity of assessing them in terms of the quality of further life. The opportunity of creating a life and having the offspring, that of getting education and a profession are one of the main characteristics of the quality of life. The data on the reproductive function and social adaptation of 443 children receiving multimodality treatment for lymphogranulomatosis by 3 protocols (from 1976, 1978, and 1987). Two hundred and fifty eight individuals were 18 years old or more. Sixty four former patients have 88 children who are all healthy. The treatment performed in childhood intensively, which yielded a complete effect, exerts no substantial impact on the formation and performance of their reproductive function. The former patients have a high intellect, without limitations in getting professions, and they are easily adaptable to the changing social conditions.

[The efficacy of different types of cholecystectomy for chronic cholecystitis]. / Effektivnost' razlichnykh vidov kholetsistéktomii po povodu khronicheskogo kholetsistita.

The results of surgical treatment of 193 patients with chronic calculous cholecystitis were analyzed. In 89 of then the ordinary cholecystectomy (OC) was conducted, in 48--cholecystectomy through the minilaparotomy access (MC), in 56--laparoscopic cholecystectomy (LC). After OC conduction the incidence of postoperative complications was the greatest. After LC conduction the complications appeared in 5 patients, they started to stand up and walk on the second day, the majority of them were discharged from the hospital in 2 days. The hospital stay duration after LC conduction was (3.8 + 1.5) days on the average, while after MC and OC-(6.2 + 1.5) and (12.4 + 2.3) days accordingly. Essential advantage of LC over OC and MC was determined.

[State of the reproductive function in women who had lymphogranulomatosis in childhood and adolescence]. / Sostoianie reproduktivnoi funktsii u zhenshchin, perenesshikh limfogranulematoz v detskom i molodnom vozraste.

As many as 33 women who received combined treatment (fully successful) at an age of 5-26 years for lymphogranulomatosis were examined. In 30 patients, the structure and function of the reproductive organs was within age norm. In 20 women, there were 20 deliveries at an age of 19-33 years, with the mean age amounting to 23 years; 10 boys and 10 girls were born. The children are healthy. The selective toxicity of the treatment as a whole and of each of its components with regard to the reproductive organs was not proved. In the authors' opinion, two cases of disease relapses in pregnant women do not form basis for recommending the woman do refrain from pregnancy in the long-term periods after the treatment of lymphogranulomatosis.

[Clinico-morphological characteristics of lymphogranulomatosis in young children]. / Kliniko-morfologicheskie osobennosti limfogranulematoza u detei rannego vozrasta.

Cases of lymphogranulomatosis underwent a clinico-morphological analysis in 67 children aged 1 year to 3 years 11 months. The morphological features of the process and distinctive traits of the clinical picture of the disease in infants were defined. The 5-year survival in patients undergoing the current treatment programs was estimated.

[Treatment of lymphogranulomatosis in children]. / Lechenie limfogranulematoza u detei.

The authors analyze the results of the treatment of 366 children afflicted with lymphogranulomatosis. All the patients received treatment from 1976 to 1990 according to three combined programs. The necessity is demonstrated of the individual treatment with regard to the predictors. Immunocorrection by means of taktivin was employed in patients with immunity disorders. The perfection of a complex of treatment measures favoured an increase of the survival to over 5 years in 93.8% of cases.

[Pathogenesis of immunologic deficiency in the initial stage of lymphogranulomatosis in children]. / Patogenez immunodefitsita v nachal'noi stadii limfogranulematoza u detei.

Antilymphocytic monoclonal antibodies of HKO and OKT series were used to study surface antigens of peripheral blood and lymph node lymphocytes in 13 untreated patients with Hodgkin's disease. The purpose of the study was to identify the pathogenetic mechanism underlying the development of immunodeficiency in the early disease stages. The data obtained have demonstrated that the deficiency of T lymphocytes in the peripheral blood was connected with that of mature T cells in the lymph nodes revealed with the use of differential antigens complex. Deficiency of immunologically differentiated T lymphocytes in the lymph nodes combined with high counts of the cells whose membranes carry Ia-like antigen point to the immunologically unfavourable course of the disease.