Assuntos
DNA/uso terapêutico , Lesões Experimentais por Radiação/tratamento farmacológico , Animais , Autoanticorpos/análise , Avaliação Pré-Clínica de Medicamentos , Feminino , Raios gama/efeitos adversos , Fígado/imunologia , Masculino , Camundongos , Músculos/imunologia , Lesões Experimentais por Radiação/imunologia , Fatores de TempoRESUMO
Investigations included 6 groups of male guinea pigs counting 50 guinea pigs in each of them. Starting from the age of 25 days the animals were kept on standard rations consisting of granulated combined fodder with diverse protein (22.8, 17.5, 13.8 per cent) and cellular tissue (11.8, 13.6, 15.7 per cent) content. The results failed to show any significant dependance of the animals' radiosensitivity on the protein and cellular tissue levels in the diet.
Assuntos
Celulose/uso terapêutico , Carboidratos da Dieta/uso terapêutico , Proteínas Alimentares/uso terapêutico , Lesões Experimentais por Radiação/prevenção & controle , Animais , Cobaias , MasculinoAssuntos
Dieta , Cobaias , Lesões Experimentais por Radiação , Animais , Cálcio , Celulose , Gorduras na Dieta , Proteínas Alimentares , Dose Letal Mediana , Masculino , FósforoRESUMO
Experiments were conducted on 220 female mice weighing 20--24 g, with the use of 3 types of antigens (sheep erythrocytes, vaccines from the intestinal and paratyphoid bacilli). There proved to be an increase on the 7th and the 14th day of the formation of specific antibodies under the effect of subcutaneous injection of a homologous blood (0.1--0.3 ml per mouse) 2 hours after the antigen immunization. Hemostimulation not only intensified the antibody-genesis, but also increased the resistance to the infection with the living microbial culture. The stimulating action of the blood injection persisted in irradiation of the mice with gamma-rays in a dose of 300 r. Hemostimulation produced an activation of the normal autoantibody system capable of influencing the function of cells necessary for the antigen assimilation.