1.
Bioorg Med Chem
; 23(15): 4681-4687, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26081764
RESUMO
A series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well. All compounds were screened against chloroquine resistant W-2 (CQ-R) and chloroquine sensitive, D-10 (CQ-S) strains of Plasmodium falciparum showing IC50 in the submicromolar range and low toxicity against human endothelial cells.