RESUMO
We studied the effect of long-term light deprivation which began at different stages of ontogeny on the content of α-tocopherol in rats during the first 3 months of postnatal development. In the offspring postnatally exposed to constant darkness, the level of α-tocopherol in the liver, kidneys, heart, skeletal muscles, and lungs was significantly decreased at the early stages of postnatal ontogeny (2 weeks and 1 month). In rats kept under constant darkness after birth, the content of α-tocopherol in the lungs was also reduced at the age of 1 month. The modulating effect of light deprivation on the level of α-tocopherol can be associated both with the impact of disturbed circadian rhythms and with increased content of melatonin in the body.
Assuntos
Rim/metabolismo , Luz , Fígado/metabolismo , Pulmão/metabolismo , Músculo Esquelético/metabolismo , Miocárdio/metabolismo , alfa-Tocoferol/metabolismo , Animais , Feminino , Rim/efeitos da radiação , Fígado/efeitos da radiação , Pulmão/efeitos da radiação , Masculino , Músculo Esquelético/efeitos da radiação , Ratos , Ratos Wistar , alfa-Tocoferol/efeitos da radiaçãoRESUMO
The aim of this work was to study the effect of various doses of vitamins A and E on the morphometric parameters and surface architectonics peculiarities of peripheral blood lymphocytes in veiled Arctic foxes. Using light microscopy, it was found that in the blood of veiled Arctic foxes (n=30) most of the lymphocytes had relatively smooth surface, and only in some cells cytoplasmic protrusions were observed. Large doses of vitamins A and E that were introduced into animal diet, caused significant reduction of morphometric parameters in relatively smooth forms of lymphocytes, while vitamin A changed the microrelief of their surface.
Assuntos
Raposas/sangue , Linfócitos/efeitos dos fármacos , Vitamina A/farmacologia , Vitamina E/farmacologia , Vitaminas/farmacologia , Animais , Citoplasma/efeitos dos fármacos , Dieta , Feminino , Linfócitos/citologiaRESUMO
Activities of antioxidant enzymes, vitamin E level, lactate dehydrogenase isoenzyme spectrum, and effects of melatonin on these parameters were studied in the myocardium of rats aged 6, 12, 18, and 24 months exposed to different illumination regimens. The greatest number of changes was recorded in rats exposed to permanent illumination and light deprivation. Activity of SOD decreased with age, while catalase activity increased. Melatonin treatment did not modify activities of antioxidant enzymes and negligibly modified the level of tocopherol and isoenzyme spectrum of lactate dehydrogenase in rat heart.
