Biochemical indicators of atherogenic and protective activity of xydiphone in experimental animals.

Atherosclerotic plaque formation and vascular calcinosis were modeled in a subchronic experiment. Reduced HDL and elevated LDL concentrations, increased atherogenic index and albumin toxicity index, and high blood levels of triglycerides and uric acid were early markers of pathology. Xydiphone in combination with vitamin D effectively reduced these changes and the degree of vascular calcinosis.