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1.
Ultraschall Med ; 40(6): 722-733, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30396216

RESUMO

PURPOSE: To evaluate the ability of a new ultrasound (US) method based on sound speed estimation (SSE) with respect to the detection, quantification, and grading of hepatic steatosis using magnetic resonance (MR) proton density fat fraction (PDFF) as the reference standard and to calculate one US fat index based on the patient's SSE. MATERIALS AND METHODS: This study received local IRB approval. Written informed consent was obtained from patients. We consecutively included N = 50 patients as the training cohort and a further N = 50 as the validation cohort who underwent both SSE and abdominal MR. Hepatic steatosis was classified according to MR-PDFF cutoffs as: S0 ≤ 6.5 %, S1 6.5 to 16.5 %, S2 16.5 to 22 %, S3 ≥ 22 %. Receiver operating curve analysis was performed to evaluate the diagnostic performance of SSE in the diagnosis of steatosis (S1-S3). Based on the optimal data fit derived from our study, we proposed a correspondence between the MR-PDFF and a US fat index. Coefficient of determination R2 was used to evaluate fit quality and was considered robust when R2 > 0.6. RESULTS: The training and validation cohorts presented mean SSE values of 1.570 ±â€Š0.026 and 1.568 ±â€Š0.023 mm/µs for S0 and 1.521 ±â€Š0.031 and 1.514 ±â€Š0.019 mm/µs for S1-S3 (p < 0.01) patients, respectively. An SSE threshold of ≤ 1.537 mm/µs had a sensitivity of 80 % and a specificity of 85.7 % in the diagnosis of steatosis (S1-S3) in the training cohort. Robust correspondence between MR-PDFF and the US fat index was found both for the training (R2 = 0.73) and the validation cohort (R2 = 0.76). CONCLUSION: SSE can be used to detect, quantify and grade liver steatosis and to calculate a US fat index.


Assuntos
Hepatopatia Gordurosa não Alcoólica , Ultrassonografia , Humanos , Fígado/diagnóstico por imagem , Imageamento por Ressonância Magnética , Hepatopatia Gordurosa não Alcoólica/diagnóstico por imagem , Projetos Piloto , Som
2.
Phys Med Biol ; 63(21): 215013, 2018 10 26.
Artigo em Inglês | MEDLINE | ID: mdl-30362461

RESUMO

The non-invasive quantification of human tissue fat fraction using easily scalable and accessible imaging technologies is crucial for the diagnosis of many diseases including liver steatosis. Here, we propose a non-invasive quantification of fat content using a highly accessible ultrasonic imaging technology. Ultrasonic echoes backscattered from human liver tissues are recombined to synthetize echoes of a virtual point-like reflector within the organs. This virtual point-like reflector is an ultrasonic analogue of artificial stars generated by laser beams in the field of astronomy, which are used to estimate the aberrations induced in the propagation medium. Here, the ultrasonic echoes from the point-like reflector provide an estimate of the Green's function relating the ultrasonic array and the reflector location and consequently represent a measurement of the aberrations induced along the ultrasonic beam travel path. Maximizing the spatial coherence of echoes backscattered from this targeted region provides an estimate of the acoustic sound speed while iteratively making the reflector more echogenic. The acoustic sound speed is dependent of the organ fat content, and we derive and cross-validate a theoretical equation relating acoustic sound speed and fat content both in phantom experiments and humans. An ultrasound-based fat fraction was found to be highly correlated with the oil paraffin concentration (R 2 = 0.985) in phantoms and well correlated with the gold standard magnetic resonance imaging proton density fat fraction measurements (R 2 = 0.73) in patients.


Assuntos
Tecido Adiposo/diagnóstico por imagem , Som , Ultrassonografia/métodos , Acústica , Humanos , Fígado/citologia , Fígado/diagnóstico por imagem , Imagens de Fantasmas
3.
Sci Rep ; 7(1): 7304, 2017 08 04.
Artigo em Inglês | MEDLINE | ID: mdl-28779069

RESUMO

The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 µm, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.


Assuntos
Mapeamento Encefálico , Encéfalo/fisiologia , Ultrassonografia , Adulto , Córtex Cerebral/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
4.
Phys Med Biol ; 62(9): 3582-3598, 2017 05 07.
Artigo em Inglês | MEDLINE | ID: mdl-28225357

RESUMO

Hepatic steatosis is a common condition, the prevalence of which is increasing along with non-alcoholic fatty liver disease (NAFLD). Currently, the most accurate noninvasive imaging method for diagnosing and quantifying hepatic steatosis is MRI, which estimates the proton-density fat fraction (PDFF) as a measure of fractional fat content. However, MRI suffers several limitations including cost, contra-indications and poor availability. Although conventional ultrasound is widely used by radiologists for hepatic steatosis assessment, it remains qualitative and operator dependent. Interestingly, the speed of sound within soft tissues is known to vary slightly from muscle (1.575 mm · µs-1) to fat (1.450 mm · µs-1). Building upon this fact, steatosis could affect liver sound speed when the fat content increases. The main objectives of this study are to propose a robust method for sound speed estimation (SSE) locally in the liver and to assess its accuracy for steatosis detection and staging. This technique was first validated on two phantoms and SSE was assessed with a precision of 0.006 and 0.003 mm · µs-1 respectively for the two phantoms. Then a preliminary clinical trial (N = 17 patients) was performed. SSE results was found to be highly correlated with MRI proton density fat fraction (R 2 = 0.69) and biopsy (AUROC = 0.952) results. This new method based on the assessment of spatio-temporal properties of the local speckle noise for SSE provides an efficient way to diagnose and stage hepatic steatosis.


Assuntos
Hepatopatia Gordurosa não Alcoólica/diagnóstico por imagem , Ultrassonografia/métodos , Feminino , Humanos , Masculino
5.
Artigo em Inglês | MEDLINE | ID: mdl-26067040

RESUMO

Over the last ten years, shear wave elastography (SWE) has seen considerable development and is now routinely used in clinics to provide mechanical characterization of tissues to improve diagnosis. The most advanced technique relies on the use of an ultrafast scanner to generate and image shear waves in real time in a 2-D plane at several thousands of frames per second. We have recently introduced 3-D ultrafast ultrasound imaging to acquire with matrix probes the 3-D propagation of shear waves generated by a dedicated radiation pressure transducer in a single acquisition. In this study, we demonstrate 3-D SWE based on ultrafast volumetric imaging in a clinically applicable configuration. A 32 × 32 matrix phased array driven by a customized, programmable, 1024-channel ultrasound system was designed to perform 4-D shear-wave imaging. A matrix phased array was used to generate and control in 3-D the shear waves inside the medium using the acoustic radiation force. The same matrix array was used with 3-D coherent plane wave compounding to perform high-quality ultrafast imaging of the shear wave propagation. Volumetric ultrafast acquisitions were then beamformed in 3-D using a delay-and-sum algorithm. 3-D volumetric maps of the shear modulus were reconstructed using a time-of-flight algorithm based on local multiscale cross-correlation of shear wave profiles in the three main directions using directional filters. Results are first presented in an isotropic homogeneous and elastic breast phantom. Then, a full 3-D stiffness reconstruction of the breast was performed in vivo on healthy volunteers. This new full 3-D ultrafast ultrasound system paves the way toward real-time 3-D SWE.


Assuntos
Técnicas de Imagem por Elasticidade/métodos , Imageamento Tridimensional/métodos , Técnicas de Imagem por Elasticidade/instrumentação , Desenho de Equipamento , Feminino , Humanos , Modelos Biológicos , Imagens de Fantasmas , Ultrassonografia Mamária
6.
Phys Med Biol ; 59(19): L1-L13, 2014 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-25207828

RESUMO

Very high frame rate ultrasound imaging has recently allowed for the extension of the applications of echography to new fields of study such as the functional imaging of the brain, cardiac electrophysiology, and the quantitative imaging of the intrinsic mechanical properties of tumors, to name a few, non-invasively and in real time. In this study, we present the first implementation of Ultrafast Ultrasound Imaging in 3D based on the use of either diverging or plane waves emanating from a sparse virtual array located behind the probe. It achieves high contrast and resolution while maintaining imaging rates of thousands of volumes per second. A customized portable ultrasound system was developed to sample 1024 independent channels and to drive a 32 × 32 matrix-array probe. Its ability to track in 3D transient phenomena occurring in the millisecond range within a single ultrafast acquisition was demonstrated for 3D Shear-Wave Imaging, 3D Ultrafast Doppler Imaging, and, finally, 3D Ultrafast combined Tissue and Flow Doppler Imaging. The propagation of shear waves was tracked in a phantom and used to characterize its stiffness. 3D Ultrafast Doppler was used to obtain 3D maps of Pulsed Doppler, Color Doppler, and Power Doppler quantities in a single acquisition and revealed, at thousands of volumes per second, the complex 3D flow patterns occurring in the ventricles of the human heart during an entire cardiac cycle, as well as the 3D in vivo interaction of blood flow and wall motion during the pulse wave in the carotid at the bifurcation. This study demonstrates the potential of 3D Ultrafast Ultrasound Imaging for the 3D mapping of stiffness, tissue motion, and flow in humans in vivo and promises new clinical applications of ultrasound with reduced intra--and inter-observer variability.


Assuntos
Artérias Carótidas/diagnóstico por imagem , Artérias Carótidas/fisiologia , Coração/fisiologia , Imageamento Tridimensional/métodos , Imagens de Fantasmas , Ultrassom/métodos , Fenômenos Fisiológicos Sanguíneos , Humanos , Interpretação de Imagem Assistida por Computador , Ultrassonografia
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