[Bolus obstruction of the distal esophagus caused by hydrophilic plant material (guar gum)]. / Bolusobstruktion des distalen Osophagus durch pflanzliche Quellstoffe (Guarmehl).

Ingestion of 5 g guar gum (Glucotard) led to complete obstruction of the distal oesophagus in a 63-year-old diabetic. A daily intake of 5 g guar gum t.i.d. with 250 ml of water had been tolerated without problems for half a year. Intake of a sufficient amount of water, as well as an undisturbed oesophageal function, are absolutely essential for the ingestion of guar gum. Since alcohol can influence the process of swelling and the consistency of the bolus, simultaneous intake of alcohol and guar gum should be strictly avoided.

[Carcinogenic effect of 1-phenyl- and 1-(pyridyl-3)-3,3-dimethyltriazenes and 1-phenyl- and 1-(pyridyl-3)-3,3-diethyltriazenes in single pre- and postnatal administration to BD IX rats]. / Karzinogene Wirkung von 1-Phenyl- und 1-(Pyridyl-3)-3,3-dimethyl-triazen sowie 1-Phenyl- und 1-(Pyridyl-3)-3,3-diäthyl-triazen bei einmaliger prä- und postnataler Verabreichung an BD IX Ratten.

1-Phenyl- and 1-(Pyridyl-3)-3,3-dimethyltriazene and the corresponding 3,3-diethyl-derivatives have been investigated for carcinogenic effects in BD IX rats following pre- and postnatal exposure. In the prenatal experiments these compounds induce no tumors in the progeny when administered on day 10 post coitum. A pronounced neurotropic carcinogenic activity was observed in the progeny only with 1-(pyridyl-3)-3,3-diethyltriazene, when administered on day 15 p.c., while the other three triazenes tested were negative or only weakly active. Carcinogenic effects were observed with the two pyridyltriazenes, when administered on day 20 p.c., shortly before birth. All four triazenes were potently carcinogenic when administered postnatally on day 1, 10, 30, 60 and 90, respectively, post partum. The neurotropic carcinogenic activity was especially pronounced with 1-(pyridyl-3)-3,3-diethyltriazene. Observed tumor rates in heart and kidney depended upon the used triazene and to a great extend upon the age of the treated animals.