RESUMO
The diagnostic yield of 101 consecutive percutaneous liver biopsies was assessed. Adequate tissue was obtained in most specimens. Even in the presence of an adequate specimen, other procedures were often necessary to rule out other diagnostic possibilities not explained nor completely ruled out by percutaneous liver biopsy alone. With the current diagnostic procedures available to the clinician which have low morbidity and low mortality, the use of blind percutaneous liver biopsy as an initial diagnostic step in certain types of liver disease should be reassessed.
Assuntos
Biópsia por Agulha/métodos , Hepatopatias/patologia , Fígado/patologia , Humanos , Cirrose Hepática Alcoólica/patologia , Hepatopatias/diagnóstico , Hepatopatias Alcoólicas/patologia , Neoplasias Hepáticas/patologiaAssuntos
Ácidos e Sais Biliares/metabolismo , Rim/enzimologia , Sulfatos/metabolismo , Sulfurtransferases/metabolismo , Animais , Cloromercurobenzoatos/farmacologia , Concentração de Íons de Hidrogênio , Iodoacetatos/farmacologia , Cinética , Fosfoadenosina Fosfossulfato/metabolismo , Ratos , Especificidade por Substrato , Sulfurtransferases/isolamento & purificaçãoRESUMO
The diagnostic yield of 101 consecutive percutaneous liver biopsies was assessed. Adequate tissue was obtained in most specimens. Even in the presence of an adequate specimen, other procedures were often necessary to rule out other diagnostic possibilities not explained nor completely ruled out by percutaneous liver biopsy alone. With the current diagnostic procedures available to the clinician which have low morbidity and low mortality, the use of blind percutaneous liver biopsy as an initial diagnostic step in certain types of liver disease should be reassessed.
RESUMO
The diagnostic yield of 101 consecutive percutaneous liver biopsies was assessed. Adequate tissue was obtained in most specimens. Even in the presence of an adequate specimen, other procedures were often necessary to rule out other diagnostic possibilities not explained nor completely ruled out by percutaneous liver biopsy alone. With the current diagnostic procedures available to the clinician which have low morbidity and low mortality, the use of blind percutaneous liver biopsy as an initial diagnostic step in certain types of liver disease should be reassessed.
RESUMO
Pseudomonas aeruginosa was found to be able to hydrolyze bile sulfate. This property was observed when lithocholate sulfate was substituted for the sulfur source in the culture medium. The addition of MgSO4 to the medium inhibited the hydrolysis of the bile sulfate.
Assuntos
Ácidos Cólicos/metabolismo , Ácido Litocólico/metabolismo , Pseudomonas aeruginosa/metabolismo , Cinética , Sulfato de Magnésio/farmacologia , SulfatosRESUMO
Although methods for measuring colloid clearance rates have been described, they are not commonly used. Rather, most clinicians rely on the relative radiocolloid accummulation in the liver and spleen as estimated by visual inspection of liver scans. This method lacks objectivity, however, and only indirectly reflects the rate of radiocolloid clearance. We have developed a noninvasive kinetic technique for measuring radiocolloid clearance by the liver, spleen, and other reticuloendothelial tissues. The clerance-rate constants obtained by this technique appear to differentiate among cirrhosis, fatty metamorphosis, hepatitis, and normal function. In normal subjects, the mean clearance-rate constants for the liver, spleen, and extrahepatosplenic reticuloendothelial system were 16.0, 1.4, and 3.4 ml/min per 100 ml of plasma, respectively. The mean hepatic clearance-rate constant was normal in hepatitis (16.8 ml/min per 100 ml), reduced in cirrhosis (5.7), and slightly reduced in fatty metamorphosis (10.4). Both the hepatic-to-splenic and the hepatic-to-extrahepatosplenic ratios of clearance-rate constants were reduced in cirrhosis and slightly reduced in fatty metamorphosis and hepatitis. Interestingly, the splenic clearance-rate constants were normal in these three diseases.
