Effect of Xymedon and Mexidol in Combination with Antineoplastic Drugs on Spermatogenesis Indicators and Functional State of Spermatozoa in Rats with Walker-256 Carcinoma.

We compared the effect of Xymedon (100 mg/kg), Mexidol (50 mg/kg), and their combination on spermatogenesis indicators and functional state of spermatozoa in rats with Walker-256 carcinoma treated with doxorubicin (4 mg/kg) and cyclophosphamide (45 mg/kg) (once intraperitoneally on day 11 after tumor cells transplantation). Xymedon and Mexidol were injected intramuscularly for 10 days starting from day 11 of the experiment. The studied parameters were evaluated on experimental days 14 and 21. We have established that gonadoprotective effect of Xymedon developed gradually and persisted longer than that of Mexidol. It manifested in an increase in the number of epithelial spermatogenesis cells (spermatogonia by 3.2 times, early spermatids by 2.2 times, late spermatids by 2.9 times, and Leydig cells by 4 times) in the testes and also the proportion of viable progressively and non-progressively motile epididymal spermatozoa (by 2 times). The combination of Xymedon and Mexidol stimulated spermatogenesis (with restoration of the initial level of spermatocytes, an increase in the number of early spermatids by 65.5 and 99% in comparison with Xymedon alone and Mexidol alone, respectively) and increased the number of viable epididymal spermatozoa more effectively than Xymedon and Mexidol alone by 54 and 60%, respectively.

Evaluation of the Possibility of Correction of Doxorubicin-Induced Chronic Heart Failure in the Experiment with 3-Hydroxypyridine Acetylcysteinate and 3-Hydroxypyridine Succinate.

The possibility of correction of morphological changes in the myocardium and biochemical parameters of the blood with 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg was studied in the model of doxorubicin-induced chronic heart failure in rats. It was found that 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg produced less pronounced cardio-protective effect in experimental chronic heart failure than 3-hydroxypyridine succinate.

Experimental substantiation for the use of mexidol and 3-hydroxypyridine fumarate in chronic myocardial injury.

We studied the cardioprotective properties of mexidol and 3-hydroxypyridine fumarate in rat model of chronic myocardial injury. We found that 3-hydroxypyridine fumarate (25 mg/kg) produced more pronounced antioxidant and cardioprotective effects than mexidol (25 mg/kg).

Efficiency of structurally different antioxidants in combined myocardial damage in mice.

Cardioprotective effects of derivatives of 3-hydroxypyridine, benzimidazole, and a peptide substance were studied on the model of combined damage to the myocardium (catecholamines and physical exercises) in mice. The most pronounced antioxidant and cardioprotective effects were produced by 3-hydroxypyridine acetylcysteinate (50 mg/kg), benzimidazole derivative Be-2m (50 mg/kg), and peptide substance γ-glutamyl histamine (1 mg/kg).

Neuroprotective activity of mexidole and 3-hydroxypyridine acetylcysteinate against the background of cerebral ischemia in the complex of experimental diabetes mellitus and exogenous hypercholesterolemia.

We studied the interaction of mexidol and 3-hydroxypyridine acetylcysteinate on the model of experimental ischemic stroke in rats. The preparations were effective in a dose 50 mg/kg (10-day treatment): they reduced the incidence of neurological disturbances (pareses, sensitivity disturbances) and improved antioxidant defense of the plasma.

[The effect of mexidol on the myelosuppressive toxicity, and on the antitumor and antimetastatic effectiveness of cyclophosphane].

Mexidol therapy inhibited cyclophosphamide-induced myelosuppression in C57B1/6 line mice with Lewis lung carcinoma without affecting antitumor action of the latter. Mexidol plus cyclophosphamide proved more effective in prophylaxis of metastasis as compared with the cytostatic alone.

[Angioprotective activity of mexicor in atherosclerosis obliterans of the lower limbs].

The authors have studied mexicor's efficacy in a comprehensive treatment of 25 patients suffering from atherosclerosis obliterans of the lower extremities with grade II-III ischaemia. The state of the vascular bed and the degree of arteries' narrowing were assessed by means of colour duplex scanning of the lower limb arteries using the unit Vivid 7 manufactured by the Company <>. The angiographic examination of the vessels of the lower extremities was carriedout on the angiographic complex manufactured by the Company Siemens Multistar T.O.P. The volume of the filling of the vessels of the lower limbs was evaluated by the parameters of the rheogram registered on the rheograph 4RG-1A. It was determined that the inclusion of mexicor (5-6% ml intravenously dropwise, 300 mg/day) into the standard therapeutic regimen significantly increased the efficacy of the conventional management of atherosclerosis obliterans of the arteries of the lower limbs, accelerating regression of the main clinical symptoms of ischaemia, increasing the distance of pain-free walking, correcting dyslipidaemia, and excreting an antioxidant action.

[Study of hepatoprotective activity of ethylmethylhydroxypyridine fumarate and lipoate in the experimental toxic hepatitis].

The authors have studied hepatoprotective actions of new derivatives of 3-hydroxipyridine on an experimental model of toxic hepatitis (140 white mice). Mexidol and berlithion are choosed as the preparations of comparison. The method of light microscopy is used for the exploration of morphological changes. The cytolytic contents activity, catalase activity and the level of MDA have been determined in blood serum. The antitoxic effect is valued by the survival of the animals. It is found that all examined bonds is corrected morphological changes in toxic hepatitis and increased the index of animals survival, which is more expressed than the preparations of comparison.

[Possible pharmacological correction of metabolic impairments experimental diabetes mellitus by antioxidant]. / Vozmozhnosti farmakologicheskoi korrektsii metabolicheskikh narushenii pri éksperimental'nom diabete preparatami antioksidantnogo tipa deistviia.

On model of experimental diabetes in rats the possibility of correction of impairments of lipid, carbohydrate and albumin metabolism by SEMOP in a dose of 25 or 5 mg/kg, dimephosphone (100 mg/kg) and alpha-tocopherol (25 mg/kg) has been Advantage of SEMOP consists in its ability to decrease a level of total protein and albumin of blood of animals with experimental diabetes.

[The effect of ximedon on adaptation to prolonged immobilization stress]. / Vliianie ksimedona na adaptatsiiu k dlitel'nomu immobilizatsionnomu stressu.

It was shown in rabbit experiments that the use of ximedon in long-term immobilization stress limits activation of lipid peroxidation, stimulates the main enzymes of the antioxidant systems, causes of hypolipidemic, preventive endotheliotropic, and cardiotropic effect.

[Effect of UV-irradiation of blood on the course of adaptation to conditions of hypodynamia]. / Vliianie UF-oblucheniia krovi na techenie adaptatsii k usloviiam gipodinamii.

The rabbit experiment has studied the impact of ultraviolet (UV) blood irradiation on the course of adaptative processes under restrictive stress. Thirty-day hypodynamia was demonstrated to result in chronic stress whose pathogenetic links are activated neutrophilic leukocytes, developed disseminated intravascular coagulation, atherogenic metabolic changes. UV blood irradiation enhanced the body's adaptative potentialities under long-term hypodynamia, by diminishing restriction-induced stress lesion.

[Effect of oxygen aeroions on hemostasis and development of arteriosclerosis in hypodynamia]. / Vliianie aéroionov kisloroda na gemostaz i razvitie arterioskleroza pri gipodinamii.

Experiments on 50 rabbits examined the hemostatic effects of negative oxygen aeroions (AI). In control experiments, keeping the animals under hypodynamia led to 40% animal death, significant aortic atherosclerosis and myocardial infarction. The animals developed the thrombohemorrhagic syndrome with hypercoagulemia and drastically suppressed blood fibrinolytic activity. Keeping the animals in the excess AI-containing premise saved all rabbits' life and prevented arteriosclerosis and myocardial infarction. Unlike the controls, these animals failed to develop the thrombohemorrhagic syndrome. Clotting time, plasma recalcification time, and plasma silicon and kaolin time did not reduce, but prolonged. There was no drop in the content of antithrombin III or rise in values of paracoagulation tests. It is recommended that Chizhevsky's electroeffluvial chandeliers should be used to prevent hemostatic disorders and arteriosclerosis in hypodynamia.

[Adaptation to exercises after exposure to restriction stress]. / Adaptatsiia k fizicheskim nagruzkam posle vozdeistviia immobilizatsionnogo stressa.

Adaptation to exercises was studied in rabbits exposed to restriction stress. Transition from 30-day inactivity to the routine motor activity and subsequent exercises was found to cause a further progression of blood atherogenic changes, ulcerative arteriosclerosis, and heart failure.

[Blood coagulation factors of the vascular wall and myocardium in hypokinesia in rabbits]. / Faktory svertyvaniia krovi sosudistoi stenki i miokarda pri gipokinezii u krolikov.

The effect of hypokinesia on the hemocoagulatory and fibrinolytic properties of aorta, myocardium and venae cavae was studied. Hypokinesia decreased thromboplastic activity of the intima and increased that of the mid- and outer layers of the aorta. Anticoagulatory properties of aortal and myocardial tissues increased whereas their antithrombin properties decreased. Rabbit immobilization increased the content of fibrinolytic stimulants in the aorta and myocardium.