1.
Chemistry
; 21(34): 11980-3, 2015 Aug 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26213326
RESUMO
A general method for the synthesis of dipeptides has been developed, which does not require any coupling reagents. This method is based on the reaction of readily available HCl salts of amino acid methyl esters with tetrabutylphosphonium amino acid ionic liquids. The isolation procedure of stepwise treatment with AcOH is easy to carry out. The method was extended to the synthesis of tripeptide, tyrosyl-glycyl-glycine, present in IMREG-1, also.
Assuntos
Aminoácidos/química , Dipeptídeos/síntese química , Indicadores e Reagentes/química , Líquidos Iônicos/química , Linfocinas/química , Oligopeptídeos/síntese química , Dipeptídeos/química , Oligopeptídeos/química
2.
Nucleosides Nucleotides Nucleic Acids
; 22(5-8): 711-3, 2003.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14565260
RESUMO
A facile method for the synthesis of 3'-alpha-fluoro-2',3'-dideoxyadenosine (5) has been developed using a novel rearrangement of 3'-beta-bromine to the 2'-beta position during 3'-alpha fluorination.
