RESUMO
Three goats with osteodystrophia fibrosa are described. The main lesions were confined to the mandibles, although in two of the three all bones were rarefied and there were longbone fractures. In two of the three goats, there was evidence of a dietary cause due to selective feeding. In the third, the history was insufficient to indicate a likely cause.
Assuntos
Doenças Ósseas Metabólicas/veterinária , Cabras , Hiperparatireoidismo Secundário/veterinária , Doenças Mandibulares/veterinária , Ração Animal/análise , Fenômenos Fisiológicos da Nutrição Animal , Animais , Doenças Ósseas Metabólicas/complicações , Doenças Ósseas Metabólicas/etiologia , Feminino , Hiperparatireoidismo Secundário/etiologia , Doenças Mandibulares/complicações , Doenças Mandibulares/etiologiaRESUMO
Transfer of an Hly plasmid determining production of alpha haemolysin to a non-haemolytic strain of Escherichia coli increased the virulence of the strain for mice. Injections of non-toxic amounts of alpha haemolysin, phenylhydrazine, haemoglobin, iron or manganese salts simulated the effect of the Hly plasmid by stimulating bacterial growth. Active or passive immunisation against alpha haemolysin protected mice on challenge with haemolytic E. coli by inhibiting in-vivo proliferation of the strain. Protection was eliminated by administration of iron salts at the time of challenge. The Hly plasmid probably acts as a virulence factor by enabling haemolytic strains of E. coli to obtain iron for growth from the lysed erythrocytes of infected animals.
Assuntos
Proteínas de Bactérias/farmacologia , Proteínas de Escherichia coli , Escherichia coli/patogenicidade , Proteínas Hemolisinas , Hemólise/efeitos dos fármacos , Ferro/metabolismo , Animais , Escherichia coli/genética , Escherichia coli/crescimento & desenvolvimento , Camundongos , PlasmídeosRESUMO
Two calves were treated with 15 micrograms/kg body weight of 1alpha-hydroxycholecalciferol by intramuscular injection on four occasions at seven-day intervals. Anorexia and reduced water consumption persisted for 48 h after each treatment. No clinical signs of iridocyclitis or any other lesions of the eyes were present at any time either macroscopically or microscopically. After the first treatment serum GOT and GD activities increased, serum AP activity fell, serum concentrations of calcium and inorganic phosphate increased, and magnesium concentrations decreased. The reduced serum magnesium concentrations and increased calcium and inorganic phosphate concentrations were maintained for the duration of the experiment, but there was no evidence of a cumulative effect of successive treatments. Blood urea concentrations increased after the third treatment. The gross pathology at post mortem examination was similar to that reported after vitamin D3 supplementation.
Assuntos
Doenças dos Bovinos/induzido quimicamente , Hidroxicolecalciferóis/toxicidade , Animais , Aorta/patologia , Nitrogênio da Ureia Sanguínea , Calcinose/induzido quimicamente , Calcinose/patologia , Calcinose/veterinária , Cálcio/sangue , Bovinos , Doenças dos Bovinos/sangue , Doenças dos Bovinos/patologia , Rim/patologia , Masculino , Miocárdio/patologia , Fosfatos/sangueRESUMO
It was found that oral immunisation of pigs with heat stable Escherichia coli antigens resulted in a decrease in the sensitivity of the porcine intestine to both the heat stable (ST) and the heat labile (LT) and the heat labile (LT) form of the enterotoxin produced by enterotoxigenic strains. Antitoxic factors capable of neutralising LT, but not ST, could be passively transferred in the intestinal secretions of the immunised animals.