RESUMO
Microcapsules of ibuprofen were prepared according to the solvent evaporation method, using two coating polymers, cellulose acetate butyrate and ethylcellulose. The influence of two emulsifying agents, polysorbat 80 and polyvinyl alcohol, on the properties of the microcapsules was investigated. The results show that type and concentration of emulsifying agent influences size distribution, drug loading and amount of free drug on the surface of the microcapsules.
Assuntos
Celulose/análogos & derivados , Química Farmacêutica/métodos , Excipientes/farmacologia , Cápsulas , Celulose/química , Ibuprofeno/administração & dosagem , Ibuprofeno/química , Polissorbatos/química , Polissorbatos/farmacologia , Álcool de Polivinil/química , Álcool de Polivinil/farmacologiaRESUMO
An emulsion-solvent evaporation method for preparation of microcapsules containing water-soluble 2-hydroxypropyl-beta-cyclodextrin complex of a lipophilic water-insoluble drug, hydrocortisone, is described. The release of the drug from the microcapsules was determined in simulated gastric fluid. The drug release rate from the microcapsules could be controlled by addition of a plasticizer and it was sustained over extended time. Addition of solubilizing compounds to the dissolution medium did not affect the drug release rate.