Assuntos
Dessensibilização Imunológica , Hipersensibilidade a Drogas/terapia , Glucosilceramidase/efeitos adversos , Hipersensibilidade Imediata/terapia , Adulto , Hipersensibilidade a Drogas/diagnóstico , Hipersensibilidade a Drogas/etiologia , Terapia de Reposição de Enzimas/efeitos adversos , Feminino , Doença de Gaucher/tratamento farmacológico , Glucosilceramidase/uso terapêutico , Humanos , Hipersensibilidade Imediata/diagnóstico , Hipersensibilidade Imediata/etiologia , Testes Cutâneos , Adulto JovemRESUMO
Ampicillin/sulbactam is a beta-lactam/beta-lactamase inhibitor combination with a broad spectrum of antibacterial activity against Gram-positive, Gram-negative and anaerobic bacteria. Data from comparative studies justify the use of ampicillin/sulbactam in a 2 : 1 ratio in various severe bacterial infections. In comparative clinical trials, ampicillin/sulbactam has proved to be a significant drug in the therapeutic armamentarium for lower respiratory tract infections and aspiration pneumonia, gynaecological/obstetrical infections, intra-abdominal infections, paediatric infections such as acute epiglottitis and periorbital cellulitis, diabetic foot infections, and skin and soft tissue infections. Of particular interest during this era of increasing antimicrobial resistance in various settings and populations is the effectiveness of sulbactam against a considerable proportion of infections due to Acinetobacter baumannii.
Assuntos
Ampicilina/uso terapêutico , Antibacterianos/uso terapêutico , Infecções Bacterianas/tratamento farmacológico , Sulbactam/uso terapêutico , Ampicilina/efeitos adversos , Ampicilina/farmacologia , Antibacterianos/efeitos adversos , Antibacterianos/farmacologia , Infecções Bacterianas/microbiologia , Combinação de Medicamentos , Farmacorresistência Bacteriana Múltipla , Bactérias Gram-Negativas , Bactérias Gram-Positivas , Humanos , Sulbactam/efeitos adversos , Sulbactam/farmacologiaRESUMO
INTRODUCTION: We sought to review the available evidence regarding the effect of psychosocial factors on the survival of breast cancer patients. METHODS: We systematically searched the PubMed and PsycINFO databases to identify relevant studies. RESULTS: We identified 31 studies examining the association of various psychosocial parameters with overall breast cancer survival/disease free survival and 6 studies examining whether psychological intervention influences the disease outcome. Of the 31 studies summarized in this overview, 25 (80.6%) showed a statistically significant association between at least one psychosocial variable and disease outcome. Parameters associated with better breast cancer prognosis are social support, marriage, and minimizing and denial, while depression and constraint of emotions are associated with decreased breast cancer survival; however, the role of these factors has not been verified in all studies. CONCLUSION: Most of the studies show a significant relationship between psychosocial factors and survival, but the actual psychosocial variables related to survival are not consistently measured across studies and the findings for many of the psychosocial variables with survival/recurrence are not consistent across studies. Thus, more research is warranted regarding the role of social support, marriage, minimizing and denial, depression and constraint of emotions on breast cancer survival.
