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1.
Front Pediatr ; 11: 1228681, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37635787

RESUMO

This study investigated the status of children with obesity before and after the COVID-19 pandemic, and the effects of lifestyle guidance on weight loss among children in Japan. We analysed the data of patients who visited our hospital after check-ups for obesity and evaluated the efficacy of lifestyle guidance. The patients were divided into groups A, B, and C (year 2011, 2019, and 2021, respectively). There were no differences in body weight, obesity index (OI), blood pressure, or alanine transaminase (ALT) levels between the groups; however, aspartate transaminase (AST) level was the highest in Group C. In Group C, only OI increased between the primary and secondary screenings; however, OI and body mass index (BMI) improved during the second screening and more children in the weight loss group followed lifestyle guidance. OI/BMI did not change over the past decade; however, short-term weight gain was significant owing to the COVID-19 pandemic, and simple guidance was effective in reducing weight. Future challenges include identifying methods to achieve long-term weight loss.

2.
Pediatr Int ; 54(4): 536-8, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22830540

RESUMO

Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza-associated encephalopathy. There was no elevation of Interleukin (IL)-1ß, which induces convulsion. The inhibitory cytokines of IL-10 and IFN-γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL-10 and IFN-γ might work to localize the lesion and to prevent sequelae.


Assuntos
Encefalite Viral/metabolismo , Influenza Humana/complicações , Influenza Humana/metabolismo , Interferon gama/biossíntese , Interleucina-10/biossíntese , Esplenopatias/metabolismo , Esplenopatias/virologia , Criança , Humanos , Masculino , Fatores de Tempo
3.
J Infect Chemother ; 18(6): 827-31, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22572852

RESUMO

Respiratory syncytial virus (RSV) infection in children can be associated with acute encephalopathy. However, the roles of cytokines in the cerebrospinal fluid (CSF) of such patients remain unevaluated. In this study, a profile of 17 cytokines was determined for eight RSV-infected children with neurological complications. In one patient with high levels of 13 cytokines, a cytokine storm was considered to have occurred. Interleukin (IL)-6, IL-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1ß levels were also high in other patients. These data suggest that chemokines in CSF play roles in neurological complications in RSV-infected children.


Assuntos
Viroses do Sistema Nervoso Central/líquido cefalorraquidiano , Quimiocinas/biossíntese , Quimiocinas/líquido cefalorraquidiano , Infecções por Vírus Respiratório Sincicial/líquido cefalorraquidiano , Vírus Sinciciais Respiratórios/isolamento & purificação , Viroses do Sistema Nervoso Central/virologia , Quimiocinas/genética , Pré-Escolar , Feminino , Genoma Viral , Humanos , Lactente , Recém-Nascido , Masculino , RNA Viral/líquido cefalorraquidiano , Infecções por Vírus Respiratório Sincicial/virologia , Vírus Sinciciais Respiratórios/genética
5.
No To Hattatsu ; 44(1): 55-9, 2012 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-22352032

RESUMO

Congenital cytomegalovirus (CMV) infection occurs frequently in neonates. However, there are no screening tests or definitive treatments for this infection in Japan. We report a case of a 21-day-old Japanese boy with congenital CMV infection. He was referred to our hospital for treatment of congenital bilateral deafness. Brain magnetic resonance imaging (MRI) revealed cortical dysplasia of the temporal poles, enlarged ventricles, and areas of abnormal intensity in the white matter. He was given a diagnosis of congenital CMV infection based on the detection of CMV DNA in his urine and the umbilical cord. After the administration of valganciclovir, no CMV DNA was detected in his serum, and brain MRI and electroencephalogram findings, motor development, and deafness improved. Further investigation is needed to establish a screening test and treatment for congenital CMV infection in Japan.


Assuntos
Antivirais/administração & dosagem , Infecções por Citomegalovirus/congênito , Infecções por Citomegalovirus/tratamento farmacológico , Ganciclovir/análogos & derivados , Anticorpos Antivirais/sangue , Biomarcadores/sangue , Biomarcadores/urina , Citomegalovirus/genética , Citomegalovirus/imunologia , Infecções por Citomegalovirus/diagnóstico , DNA Viral/urina , Eletroencefalografia , Ganciclovir/administração & dosagem , Humanos , Imunoglobulina M/sangue , Recém-Nascido , Imageamento por Ressonância Magnética , Masculino , Resultado do Tratamento , Valganciclovir
6.
Pediatr Int ; 54(1): 86-8, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22136601

RESUMO

BACKGROUND: Children infected with rotavirus often show increased levels of transaminase, and symptoms are characterized by white stool, similar to biliary atresia. Rotavirus infections are also sporadically accompanied with convulsions, encephalopathy and Reye syndrome. The aim of the present study was therefore to investigate transaminase and interleukin (IL)-6 levels in rotavirus infection, in order to better understand their clinical significance. METHODS: Results of liver function tests, mainly the elevation of transaminase and IL-6 in rotavirus gastroenteritis with or without convulsions, were evaluated. RESULTS: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were high in 23 of 26 samples (88.5%), and in three of 26 samples (11.5%), respectively. No significant differences in liver function tests could be found between the groups with or without convulsions. Three patients whose direct bilirubin levels were above the upper normal limit were all classified into the group without convulsions. Spearman's correlation coefficient was 0.89 between increasing AST levels and IL-6 levels. CONCLUSION: Rotavirus infection is occasionally accompanied with hepatitis, but only in a mild form, and does not correlate with neurological complications. High levels of transaminase might reflect high IL-6.


Assuntos
Alanina Transaminase/sangue , Aspartato Aminotransferases/sangue , Gastroenterite/virologia , Interleucina-6/sangue , Infecções por Rotavirus/sangue , Convulsões/sangue , Pré-Escolar , Feminino , Gastroenterite/sangue , Humanos , Lactente , Testes de Função Hepática , Masculino , Estudos Retrospectivos , Infecções por Rotavirus/complicações , Convulsões/virologia
7.
Artigo em Inglês | MEDLINE | ID: mdl-22084613

RESUMO

This report concerns a 12-year-old male with intractable seizures over a long period. The case fulfilled the diagnostic criteria for nonherpetic acute limbic encephalitis. He had frequent convulsions starting with a partial seizure at the left angle of the mouth and progressing to secondary generalized seizures. He was treated with several anticonvulsants, combined with methylprednisolone and γ-globulin under mechanical ventilation. However, his convulsions reappeared after tapering of the barbiturate. His magnetic resonance imaging showed a high intensity area in the hippocampus by FLAIR and diffusion. After five months he recovered without serious sequelae. Virological studies, including for herpes simplex virus, were all negative. He was transiently positive for antiglutamate receptor antibodies in cerebrospinal fluid and serum.

9.
J Infect Chemother ; 17(6): 776-81, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21647570

RESUMO

Infection with respiratory syncytial virus (RSV) is known to be associated with central nervous system symptoms such as convulsions. We investigated cytokines, nitrogen oxide (NO)( x ), and the viral genome in cerebrospinal fluid (CSF) obtained from children with RSV infection-related convulsions or central nervous symptoms and compared the data with type of encephalopathy. Of nine patients enrolled (six boys and three girls; aged 10 days-3 years), one metabolic error, five excitotoxicity, one cytokine storm, and two hypoxia cases were found. The patients presented with unilateral convulsions, generalized convulsions, and convulsions following cardiopulmonary arrest, apnea, and nuchal rigidity. In all patients, a rapid check for RSV of nasal fluid was positive. The RSV genome (subgroup A) was detected in the CSF of five of the nine patients; two patients with hypoxic encephalopathy were negative for the RSV genome. The CSF interleukin (IL)-6 levels were high only in patients with the excitotoxicity and cytokine storm type of encephalopathy. NO( x ) levels were high in all the subject cases. In the excitotoxicity type, NO( x ) levels were significantly higher than those in the control and other groups. NO( x ) level may become an important parameter for the diagnosis and classification of acute encephalopathy in RSV. Strategies to treat each type of encephalopathy, targeting cytokines and free radicals, should be established.


Assuntos
Infecções do Sistema Nervoso Central/classificação , Infecções por Vírus Respiratório Sincicial/classificação , Doença Aguda , Infecções do Sistema Nervoso Central/líquido cefalorraquidiano , Infecções do Sistema Nervoso Central/virologia , Pré-Escolar , Transtornos da Consciência/líquido cefalorraquidiano , Transtornos da Consciência/virologia , Citocinas/líquido cefalorraquidiano , Feminino , Genoma Viral , Humanos , Hipóxia-Isquemia Encefálica/líquido cefalorraquidiano , Hipóxia-Isquemia Encefálica/virologia , Lactente , Recém-Nascido , Interleucina-6/líquido cefalorraquidiano , Masculino , Óxidos de Nitrogênio/líquido cefalorraquidiano , RNA Viral/líquido cefalorraquidiano , Infecções por Vírus Respiratório Sincicial/líquido cefalorraquidiano , Infecções por Vírus Respiratório Sincicial/virologia , Vírus Sinciciais Respiratórios/genética , Vírus Sinciciais Respiratórios/isolamento & purificação , Convulsões/líquido cefalorraquidiano , Convulsões/virologia
10.
Pediatr Int ; 53(2): 159-61, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21501304

RESUMO

BACKGROUND: Neuromuscular disorders can be the cause of sudden death of infants because of their weakness and gastroesophageal reflux (GER). METHODS: Muscle biopsy and genetic studies were performed by usual method. RESULTS: In this report four cases of infants with neuromuscular disorders (two cases of congenital myopathy and two cases of spinal muscular atrophy) who had unexpected cardiopulmonary arrest on arrival (CPAOA) are presented. Two of the cases did not show any symptoms, such as muscle weakness prior to CPAOA. The diagnosis was based on the results of the muscle biopsy and genetic examination. CONCLUSION: These results suggest that sudden infant death caused by neuromuscular disorders should be considered.


Assuntos
Parada Cardíaca/etiologia , Doenças Musculares/complicações , Atrofias Musculares Espinais da Infância/complicações , Morte Súbita do Lactente/etiologia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Miopatias da Nemalina/complicações , Miopatias Congênitas Estruturais
15.
Pediatr Int ; 50(3): 284-6, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18533937

RESUMO

BACKGROUND: In the pathology of autoimmune hepatitis the immunity mechanism of T-helper 1 (Th1) and Th2 cells was recently evaluated. The purpose of the present study was to measure the mRNA levels in peripheral mononuclear cells and serum cytokines obtained from children with autoimmune hepatitis for a better understanding of the mechanism. METHODS: Twenty-five patients with autoimmune hepatitis and seven controls were enrolled. mRNA levels in peripheral mononuclear cells and serum cytokines were measured using real-time polymerase chain reaction and immunoassay. RESULTS: Serum interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) were rarely detected. In contrast the IFN-gamma/beta-actin mRNA levels were high. CONCLUSION: Autoimmune hepatitis is a Th1-predominant state, therefore immune modulation therapies that target the control of Th1 cytokines should be used.


Assuntos
Expressão Gênica , Hepatite Autoimune/genética , Interferon gama/genética , Interleucina-4/genética , RNA Mensageiro/genética , Células Th1/metabolismo , Células Th2/metabolismo , Actinas/biossíntese , Actinas/genética , Adolescente , Adulto , Biomarcadores/sangue , Criança , Pré-Escolar , Hepatite Autoimune/sangue , Hepatite Autoimune/imunologia , Humanos , Imunoensaio , Interferon gama/biossíntese , Interleucina-4/biossíntese , Reação em Cadeia da Polimerase , Prognóstico , Células Th1/imunologia , Células Th2/imunologia
16.
J Clin Lab Anal ; 22(3): 216-9, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18484653

RESUMO

For a better understanding of the role of the viral load, free radicals, and cytokines in viral meningitis, we surveyed cerebrospinal fluid (CSF) obtained from patients below 1 year of age who showed positive for enterovirus. In their first examinations interleukin (IL)-6 and free radicals increased whereas pleocytosis was rarely observed. IL-6 decreased within the short period. Viral loads and free radicals increased simultaneously. IL-6 and free radicals of CSF are helpful for diagnosis and treatment of viral meningitis at an early stage.


Assuntos
Infecções por Enterovirus/líquido cefalorraquidiano , Meningite Viral/líquido cefalorraquidiano , Carga Viral , Enterovirus/fisiologia , Infecções por Enterovirus/induzido quimicamente , Infecções por Enterovirus/virologia , Feminino , Radicais Livres/líquido cefalorraquidiano , Humanos , Imunoglobulinas Intravenosas/administração & dosagem , Lactente , Recém-Nascido , Interleucina-6/líquido cefalorraquidiano , Masculino , Meningite Viral/diagnóstico , Meningite Viral/virologia , RNA Viral/líquido cefalorraquidiano , Resultado do Tratamento
17.
Clin Med Case Rep ; 1: 33-5, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-24179342

RESUMO

We report a four-year-old Japanese girl with hyper IgD and periodic fever syndrome. There is a first report of hyper IgD syndrome (HIDS) of which the genomic study was done in Japan. In this report a girl complained of periodic fever and abdominal symptoms accompanied with high levels of mevalonic acid in urine and serum. She has been well controlled by non-steroidal anti-inflammatory drugs (NSAIDs) for 3 years.

19.
Microbiol Immunol ; 51(1): 53-62, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17237599

RESUMO

We report three infants and one teenager with fatal virus-associated haemophagocytic syndrome (VAHS). Two infants were admitted to our hospital because of cardio-pulmonary arrest (CPA). The third infant was admitted to our department because of fever and liver dysfunction, and he was diagnosed as combined immunodeficiency with predominant T cell defect. The teenager was diagnosed as systemic lupus erythema (SLE) when she was 10 years old and admitted to our department because of fever and thrombocytopenia . The histological findings for the four patients' organs revealed many haemophagocytic cells . The patients were infected by Parainfluenza virus type 2 (PIV2), Enterovirus (EV), Cytomegalovirus (CMV), and Epstein-Barr virus (EBV), respectively. Their laboratory data revealed elevated levels of ferritin and IL-6, which also suggested virus-associated haemophagocytic syndrome (VAHS). Although aggressive therapies were performed in all cases, the outcome was fatal. Further investigation would be needed to clarify the mechanism of VAHS and an effective therapeutic regimen is needed.


Assuntos
Infecções por Enterovirus/patologia , Linfo-Histiocitose Hemofagocítica/imunologia , Linfo-Histiocitose Hemofagocítica/virologia , Adolescente , Medula Óssea/patologia , Citomegalovirus/isolamento & purificação , Enterovirus/isolamento & purificação , Infecções por Enterovirus/imunologia , Infecções por Enterovirus/fisiopatologia , Evolução Fatal , Feminino , Ferritinas/sangue , Infecções por Herpesviridae/imunologia , Infecções por Herpesviridae/patologia , Infecções por Herpesviridae/virologia , Herpesvirus Humano 4/isolamento & purificação , Humanos , Lactente , Interleucina-6/sangue , Rim/patologia , Fígado/patologia , Pulmão/patologia , Linfo-Histiocitose Hemofagocítica/patologia , Masculino , Vírus da Parainfluenza 2 Humana/isolamento & purificação , Infecções por Rubulavirus/imunologia , Infecções por Rubulavirus/patologia , Infecções por Rubulavirus/fisiopatologia
20.
J Clin Gastroenterol ; 40(10): 956-8, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17063118

RESUMO

We present a rare case of hydranencephaly with cholestasis and giant hepatitis. Studies for infectious agents were all negative including for the detection of virus in liver tissue by using polymerase chain reaction. Although the anterior pituitary functions (cortisol, thyroid stimulating hormone, free T4, human growth hormone) were normal, the patient revealed massive cholestasis and giant hepatitis.


Assuntos
Colestase/patologia , Hepatite/patologia , Hidranencefalia/patologia , Biomarcadores/sangue , Biomarcadores/urina , Colestase/congênito , Colestase/diagnóstico , Colestase/metabolismo , Evolução Fatal , Feminino , Insuficiência Hepática/congênito , Insuficiência Hepática/metabolismo , Insuficiência Hepática/patologia , Hepatite/congênito , Hepatite/diagnóstico , Hepatite/metabolismo , Humanos , Hidranencefalia/diagnóstico , Hidranencefalia/metabolismo , Lactente , Tomografia Computadorizada por Raios X , Ultrassonografia de Intervenção
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