[Determining the level of occurrence of the lipid nucleus of atherosclerotic plaques in the abdominal aorta by means of infrared Fourier spectroscopy].

The article deals with the problem of diagnosis of atherosclerotic alterations in abdominal aorta wall in order to reduce atherosclerosis-related mortality. Targeted treatment requires determining the exact mechanism of development of atherosclerosis. Infrared Fourier spectroscopy is suggested as the most rapid and accurate method of diagnosis and analysis of the content of various organic compounds playing a particular role in the development of the atherosclerotic process. Presented herein are the results of studying various types of fluctuations, whose absorption bands correspond to such organic compounds as collagen, elastin and cholesterol esters. A peculiar feature of this technique consists in a new method of the preparation of the material, including preparation of samples to be studied, with no stage of fixation. Analysed herein is one of the pathogenetic mechanisms of the development of the atherosclerotic process, consisting in accumulation in the vascular intima of low and very low density lipoproteins which are detected at a frequency of 1745 cm(-1), corresponding to stretching vibrations of the C=O bond. These organic compounds saturate from the inside the vascular wall, thus leading to formation of a lipid nucleus of an atherosclerotic plaque, whose centre is located at a certain depth. The authors present the results of studying the level of the centre of the lipid nucleus of an atherosclerotic plaque in abdominal aorta in perished 70-74-year-old people. It was determined that for this age group the level of the lipid nucleus is concentrated at a depth of 200-240 µm. Besides, presented are the results obtained while studying the abdominal aorta in 23-26-year-old deceased people whose vessels were not affected by atherosclerosis. Obtained are comparative results on the shift in bandwidth of amid I and amid II in studying the intima of the healthy aorta and atherosclerosis-affected aorta. This peculiarity may later on become an identifier of the degree of the development of atherosclerosis in man. The results of such studies provide possibility to influence namely the centre of the lipid nucleus as one of the initial stages of the development of atherosclerosis in order to slow down the progression of the disease concerned.

[A comparative study of the myeloprotective effect of dicarbamine and leucostim in experimental post-radiation bone marrow syndrome].

We studied the effect of dicarbamine and leucostim on myelopoiesis in experimental post-radiation bone marrow syndrome. Dicarbamine in different modes of administration and doses provided a high level of protection of proliferating hematopoietic precursors in the early period after radiation, which was reflected in a statistically significant decrease in the depth and duration of post-radiation deficit of cells, such as of granulocytes, lymphocytes, megakaryocytes and erythroid cells. The greatest effect of the drug appeared at a dose of 4 mg/kg (prophylactic administration) and a dose of 15 mg/kg (curative double dose). In the bone marrow of experimental animals leucostim prevented development of post-radiation deficit of granulocytes and lymphocytes to a lesser extent, than dicarbamine, and it was effective for erythroid cells and megakaryocytes.

[Comparative study of the hemato-protective effect of Dicarbamine and Leykostime in experimental radiation damage to the blood system].

There was studied the influence Dicarbamine and Leykostime on peripheral blood leukocyte composition of rabbits in experimental radiogenic damage to the blood system. Dicarbamine significantly insured the safety of circulating red blood cells, prevented the development of severe postradiation thrombocytopenia, reduced postradiation leukocytopenia, and accelerated the recovery of peripheral blood leukocytes to the initial level by segmented neutrophils and lymphocytes. Leukostime ensured the safety of peripheral blood leukocytes however was less effective than Dicarbamine to prevent postradiation deficit of circulating red blood cells and thrombocytes.

[Modification of hematosupressive action of ionizing radiation by dicarbamine].

There was studied the effect of different doses of Dicarbamine by means of oral medical-prophylactic and medical administration on the peripheral blood of rabbits in conditions of experimental radiation damage to the blood system. The drug provided the safety of circulating red blood cells at rather high level, prevented the development of severe post-radiation thrombocytopenia, reduced post-radiation leukocytopenia, accelerated processes of recovery of peripheral blood leukocytes to the initial level by segmented neutrophils and lymphocytes.

[Effect of dicarbamine on medullary hemopoiesis in experimental post-irradiation bone-marrow syndrome].

The effect of dicarbamine on hemopoiesis in experimental post-irradiation bone-marrow syndrome was studied. The myeloprotective activity of the drug was established. It manifested in the protection of hematopoietic progenitor cells and stimulation of cell proliferation and differentiation in the bone marrow.