[Studying of sclerosing action of the foam form of polidokanol in experiment in vivo].

The results of investigation on impact of the foam form of sclerosant in experiment on 80 mongrel white rats, were presented. Sclerosing action of 0.5%, 2%, 3% solution of polydocanol in a microfoam form was studied after its infusion into lateral caudal vein of the rat. Quantity of preparation 0,5 cm3 was determined in accordance to the vein volume. Clinical and macroscopic estimation of the preparation action on internal organs and caudal rat's vein was conducted on the 10th min, every day during 1 week and on the 30th day. When the foam form of sclerosant is introduced intravenously there was not observed thrombotic complications of posterior vena cava and specific macroscopic changes in internal organs, not depending from its concentration, what witnesses security of the method, and selection of the sclerosant solution concentration must depend on the vessel diameter.

[Clinico-morphological comparisons in thyroid diseases (based on data from the Kiev Province Clinical Hospital)]. / Kliniko-morfologicheskie sopostavleniia pri zabolevaniiakh shchitovidnoi zhelezy (po materialam Kievskoi oblastnoi klinicheskoi bol'nitsy).

In the paper, a brief clinical account is provided of surgically treated patients suffering from varying type goiter; findings from preoperational radioimmunologic examination of patients with nodular goiter and mixed euthyroid goiter and Hashimoto's goiter are presented. An increase was found to be the case in 1989-1990, in specific weight of low-grade forms of thyroid cancer (struma maligna) as per total number of patients operated on in the clinic.

[The clinico-morphological classification of changes in the microcirculatory bed]. / Kliniko-morfolohichna klasyfikatsiia zmin mikrotsyrkuliatornoho rusla.

An autopsy-based study was made of the microcirculatory bed (MCB) of human heart in ischemic heart disease and arterial hypertension in an age-related aspect. Changes in MCB and its time course were studied in experimental models. On the basis of the studies done and data from the published literature we elaborated a morphological classification of MCB which include the following stages: compensatory; initial pathologic changes with the adaptation being maintained at the same level as before; profound pathological changes at the background of lowered adaptation; decompensation. The classification outlined above may be used in examining autopsy and biopsy material (experimental or perioperative) as well as in clinical investigations designed to study the nail bed, bulbar, conjunctiva, rectal mucous membrane. Investigation into MCB changes will enable us to properly assess adaptive potential and prescribe pathogenically substantiated surgical, internal or complex health resort treatment.

[Heart lesions in mice with experimental infection caused by Coxsackie virus A13]. / Porazheniia serdtsa u myshei pri éksperimental'noi infektsii, vyzvannoi virusom koksaki A13

The results of pathomorphological and virological studies of experimental Coxsackie A 13 virus infection in BALB/C mice are described. Chronic myocarditis, endocarditis and valvulitis were observed in mice inoculated 10 to 12 hours after birth. The virus was revealed in the infected mice for 15-20 days only.