[Autoradiography of DNA synthesis in colonic mucosa of patients with familial adenomatosis coli]. / Autoradiografische Untersuchung der DNA-Synthese in der Kolon-Mukosa von Patienten mit familiärer Adenomatosis coli.

In connection with routine endoscopic examinations of 31 patients with familial adenomatosis coli and 28 health kindreds of patients with familial adenomatosis coli we investigated by autoradiography the in vitro incorporation of 3H-thymidine into bioptic mucosal particles from colon and adenomas. Within the 5-year follow-up period there was found a significantly increased labelling index of polyps and the surrounding mucosa in patients with polyposis independing on the time elapsed after operation. In 12 of 28 kindreds the histological normal colonic mucosa showed an increased labelling index too. The prognostic value of these results must be proofed by further controls.

[Atrophic corpus gastritis and autoimmune gastritis]. / Atrophische Korpusgastritis und Autoimmungastritis.

The authors tried to clarify relations between autoimmune gastritis and isolated atrophic corpus gastritis by bioptic corporal and antral examinations from 150 probands as well as examinations of gastrin in serum and parietal cell antibody tests. Only 30% of all patients examined with isolated atrophic gastritis of the corpus part revealed criteria of an autoimmune gastritis. Therefore investigations of antibodies against parietal cells are necessary to mark off both clinical pictures. This differentiation seems to be necessary regarding the high risk of gastric cancer following an autoimmune gastritis.

[Signet-ring-cell lymphoma. Light and electron microscopic study of gastric involvement]. / Das Siegelringzellymphom Eine licht- und elektronenmikroskopische Studie bei Befall des Magens.

The authors report on a malignant Non-Hodgkin lymphoma of the stomach of a 73-year-old male. Histologically, it was revealed to be a follicularly growing, obviously secondary centroblastic lymphoma. Crystalline cytoplasmic inclusions in numerous centrocytes have led to displacement of the nucleus to the cell margin and thus to the picture of a signet-ring-cell lymphoma. Electronmicroscopically, there were found big crystalline electron-dense deposits in the rough endoplasmic reticulum. The finding was compared with literature data, and the histological differential diagnosis is discussed.

[Endoscopic and histologic findings in malignant non-Hodgkin lymphomas of the stomach]. / Endoskopische und histologische Befunde bei malignen Non-Hodgkin-Lymphomen des Magens.

The authors have carried out a retrospective analysis of primary malignant Non-Hodgkin-lymphomas of the stomach verified histologically by surgical specimens, with the patients being submitted preoperatively to a gastroscopy with biopsy. The endoscopic and histological findings are outlined. Endoscopically the diagnosis of a malignant lymphoma was established only once, while an ulcerated carcinoma was diagnosed in almost two-thirds of the cases. The histological diagnosis of a malignant lymphoma was established in 10 cases, and a malignant lymphoma suspected in 6 cases. A carcinoma was diagnosed in 4 patients. The results are compared with the literature data and diagnostic problems discussed.

[Primary malignant non-Hodgkin's lymphoma of the stomach in the Kiel classification]. / Das primäre maligne Non-Hodgkin-Lymphom des Magens in der Kiel-Klassifikation.

Resection preparations from 30 cases of primary malignant non-Hodgkin lymphomas of the stomach were reclassified using the Kiel-classification. In 17 cases centroblastic malignant lymphomas were found a further 4 were centroblastic-centrocytic, 4 were immunoblastic malignant lymphomas, and 5 immunocytic malignant lymphomas. Although preoperative gastroscopies and biopsies were carried out in 22 cases, certain diagnoses of lymphoma were possible in 9 cases only. Seven patients died within a month postoperatively. The two-year survival rate was more than one-third, and the five-year survival rate, less than one-fourth of all cases. The results are compared with data from the literature.

[Parietal cell antibodies and stomach cancer]. / Belegzellantikörper und Magenkarzinom.

Sera of 101 patients with histologically confirmed gastric cancers were investigated for parietal cell antibodies, which are the serological markers of chronic atrophic gastritis type A. These autoantibodies were more often found in patients with early than with advanced gastric cancers. They were more frequent in intestinal than in diffuse gastric cancers. It is discussed that in advanced cancers the frequency of parietal cell antibody is diminishing because of loss of antigene or binding of antibodies in immune complexes. Early gastric cancers therefore seem to be more suitable than advanced cancers to study the relation between gastric cancer and gastritis type.

[Therapeutic aspects of endoscopic polypectomy]. / Therapeutische Aspekte der endoskopischen Polypektomie.

466 endoscopic polypectomies of the upper and lower gastrointestinal tract were analysed according to their curative value. In 254 removed polyps of the upper gastrointestinal tract the result of the histological examination was twice a proof of a carcinoma. One it had to be after-resected, once a carcinoid, five times bleeding polyps were removed. Four times prolapsing gastric polyps were removed in the bulbus duodeni. In these cases intermittent disturbances of the passage could be repaired. Thus the endoscopic polypectomy in the upper gastrointestinal tract was of therapeutic value in 4.3%. In the lower intestinal tract in 204 polypectomies 16 focal carcinomas or invasive carcinomas removed in the healthy tissue, 1 carcinoid and 98 bleeding adenomas were cut away. Thus the coloscopic polypectomy was connected with a therapeutic use in 56.3%. 81.8% of the polyps was tubular, papillary or villous adenomas. Taking into consideration the "adenoma-cancer-sequence", the coloscopic polypectomy must thus be regarded as a prophylactic and curative method, while in the polypectomy in the upper gastrointestinal tract the diagnostic value is in the first place.