1.
Infect Dis Ther
; 12(3): 829-841, 2023 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36877435
RESUMO
Bacteria acquire ß-lactam resistance through a multitude of mechanisms among which production of ß-lactamases (enzymes that hydrolyze ß-lactams) is the most common, especially in Gram-negatives. Structural changes in the high-molecular-weight, essential penicillin-binding proteins (PBPs) are widespread in Gram-positives and increasingly reported in Gram-negatives. PBP-mediated resistance is largely achieved by accumulation of mutation(s) resulting in reduced binding affinities of ß-lactams. Herein, we discuss PBP-mediated resistance among ESKAPE pathogens that cause diverse hospital- and community-acquired infections globally.
2.
Lancet Infect Dis
; 23(6): 645-647, 2023 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36731479