[Effect of a new central adrenolytic on cardiac metabolic indices in neurogenic damage]. / Vliianie novogo tsentral'nogo adrenolitika na nekotorye pokazateli metabolizma serdtsa pri ego neirogennom povrezhdenii.

It is shown that in rabbits subjected to an electric stimulation of the aortic arch there developed concurrently with depletion of tissular norepinephrine reserves in the myocardium also gross metabolic disorders. A preliminary introduction of the drug izm-611 by blocking central alpha-adrenoreseptors at the same time prevented depletion of the tissular norepinephrine reserves and development of disturbances of the energy exchange in the myocardium caused by its neurogenic damage.

[Prophylactic and therapeutic action of etimizol on the change in myocardial tissue metabolism in a neurogenic lesion]. / Profilakticheskoe i lechebnoe deistvie étimizola na izmenenie tkanevogo obmena miokarda pri ego neirogennom porazhenii

The effect of aethimizol, introduced to rabbits before and after inflicting a 3-hours long extraordinary stimulation applied to the reflexogenic zone of the aortic arch, was studied. Investigations covered some aspects of energy metabolism and the level of the norepinephrine mediator in the muscle of the heart and also the functional state of the latter. Aethimizol was found to prevent shifts of the studied metabolic factors, induced by electric stimulation, and also to avert depletion of norepinephrine in the tissue of the myocardium and normalize its function.