RESUMO
The expression of molecular markers characterizing activity of the tumor process and metastases (proliferation marker Ki-67, angiogenesis marker CD34, and lymphangiogenesis markers podoplanin and LYVE-1) was assessed by immunohictochemical method in the primary tumor specimens collected during surgery for cutaneous melanoma (40 patients). Proliferative activity of the tumor tissue and volume density of peritumoral blood and lymph vessels increased with increasing tumor malignancy, which could indicate the risk of metastases.
Assuntos
Linfangiogênese/fisiologia , Melanoma/metabolismo , Neovascularização Patológica/metabolismo , Neoplasias Cutâneas/metabolismo , Adulto , Antígenos CD34/metabolismo , Proliferação de Células/fisiologia , Feminino , Humanos , Imuno-Histoquímica , Técnicas In Vitro , Antígeno Ki-67/metabolismo , Masculino , Glicoproteínas de Membrana/metabolismo , Proteínas de Transporte Vesicular/metabolismo , Melanoma Maligno CutâneoRESUMO
The article demonstrates that in patients with adenomas of stomach the concentration of pepsinogen I in blood serum and the rate between pepsinogen I and pepsinogen II is decreased. In case of adenomas and adenocarcinomas of stomach the concentration of pepsinogen I and the rate between pepsinogen I and pepsinogen II are in inverse correlation relationship with indicators of proliferative activity of epithelial cells and tumor cells correspondingly. The threshold level was the rate between pepsinogen I and pepsinogen II can be used as criteria of intensity ofproliferative activity of epithelial cells of adenomas and cells of adenocarcinomas of stomach.
