RESUMO
Clonal studies define the proteic sequence of several allergens leading to the recombination and the use of them for immunotherapy extracts. It has been possible to clone the receptors for IgE in basophils and mast cells and the regulation mechanisms had been delucidates. In a near future it will be possible to design recombinant molecules for the specific inhibition of synthesis and receptors of IgE and avoid the signal transmissions and the release of mediators. The diagnosis of several diseases is based in molecular techniques, inclusive in uterus. Genes for various diseases had been cloned in immunology, recombinations with gamma interferon had been used for treatment of subjects with atopic dermatitis and chronic granulomatous disease.
Assuntos
Biologia Molecular , Alérgenos/química , Alérgenos/genética , Clonagem Molecular , Técnicas Genéticas , Objetivos , Humanos , Hipersensibilidade/genética , Hipersensibilidade/imunologia , Síndromes de Imunodeficiência/diagnóstico , Síndromes de Imunodeficiência/genética , Complexo Principal de Histocompatibilidade/genética , Biologia Molecular/métodos , Receptores de IgE/antagonistas & inibidores , Receptores de IgE/genéticaRESUMO
Clonal studies define the proteic sequence of several allergens leading to the recombination and the use of them for immunotherapy extracts. It has been possible to clone the receptors for IgE in basophils and mast cells and the regulation mechanisms had been delucidated. In a near future it will be possible to design recombinant molecules for the specific inhibition of synthesis and receptors of IgE and avoid the signal transmissions and the release of mediators. The diagnosis of several diseases is based in molecular techniques, inclusive in uterus. Genes for various diseases had been cloned in immunology; recombinations with gamma interferon had been used for treatment of subjects with atopic dermatitis and chronic granulomatous disease.
Assuntos
Biologia Molecular/métodos , Humanos , Hipersensibilidade/diagnóstico , Hipersensibilidade/terapia , Doenças do Sistema Imunitário/diagnóstico , Doenças do Sistema Imunitário/terapiaRESUMO
Methotrexate represents a new therapeutic modality in patients with corticoresistant asthma. Its mechanism of action is the competitive inhibition of the folate reducing enzyme, converting folic acid in tetrahydrofolate during the S phase of the cell cycle. It is 50% fixed to albumin and excreted by glomerular filtration and proximal tubule secretion.
