[Morphological and histochemical analysis of central effects of angiotensin-II after experience of emotional stress]. / Morfologicheskii i gistokhimicheskii analiz tsentral'nogo éffekta angiotenzina-II na fone perenesennogo émotsional'nogo stressa.

It was shown in our physiological study that angiotensin-II induced drinking behavior was changed in previously stress exposed rats as compared to control animals. In order to determine the structural basis of the data obtained in the morphology and histochemistry (nucleic acids concentration) of the nucleus paraventricularis (n. PV), nucleus supraopticus (n. SO) and subfornical organ (SFO) neurons were studied in rats of several experimental groups. The most pronounced changes manifested the shape increase of the neurons functional activity after angiotensin-II (A-II) infusion into control and especially into previously stressed rats were discovered in n. PV. It was supposed that the disturbance of A-II-induced drinking behavior in stressed rats might be mainly due to the disfunction of n. PV neurons.

[Structural bases of the induction of immune reactions in emotional stress]. / Strukturnye osnovy induktsii immunnykh reaktsii pri émotsional'nom stresse.

Immobilization stress in rats can provoke damages of the brain parenchymal vessels, which are most pronounced in the reticular formation of the midbrain. In this case the blood plasma and cells enter the brain and the blood elements of brain tissue enter the circulation. Some experimental animals exhibit the serum complement-fixing brain antibodies and specific reactions of basophils to brain antigens 14 days after exposure to stress. Most of the rats reveal immune reactions and neurosensitivity a month later. Some of them exhibit the autoantibodies to norepinephrine and serotonin. It is suggested that stress-induced brain vascular damages may play an important role in the mechanisms of immune reaction induction.

[Allergic encephalomyelitis in guinea pigs on the intracutaneous and subcutaneous administration of fragment 114-122 of the human myelin cationic protein]. / Allergicheskii éntsefalomielit u morskikh svinok pri vnutrikozhnom i podkozhnom vvedenii fragmenta 114-122 kationnogo belka mielina cheloveka.

Single intracutaneous injection of 30 micrograms of human basic myelin protein peptide 114-122 (H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH) with Freund adjuvant induced the onset of encephalomyelitis on day 9-19 after the injection. The lethality was 33%. In autumn the disease was more severe than in summer.