[The structural bases of the cardiotoxic action of the anti-tumor antibiotic carminomycin]. / Strukturnye osnovy kardiotoksicheskogo deistviia protivoopukholevogo antibniotika karminomitsina.

The authors substantiate morphological and structural-functional basis of the cardiotoxic effect of the antitumor anthracycline antibiotic carminomycin after its single intraperitoneal administration in maximum tolerable doses. Results indicate that the cause of development of cardiac failure after administration of carminomycin to experimental animals in the development of an alternative and plastic cardiac failure prevalence of type I.

[The morphological aspects of the protective action of enterosorbent K(2)9 during the use of the antitumor anthracycline antibiotic carminomycin]. / Morfologicheskie aspekty protektornogo deistviia énterosorbenta K(2)9 pri primenenii protivoopukholevogo antratsiklinovogo antibiotika karminomitsina.

The authors substantiate morphologically the protector effect of K(2)9 enterosorbent during its parallel use with the antitumour anthracyclin antibiotic carminomycin. The agent was administered intraperitoneally in animals at the maximum tolerable dose. Use of the K(2)9 enterosorbent reduces the cardiotoxic effect of carminomycin.

[The structural bases of heart failure in ischemic heart disease]. / Strukturnye osnovy serdechnoi nedostatel'nosti pri ishemicheskoi bolezni serdtsa.

Regularities of structural changes and pathogenesis of pathological processes in the myocardium in intermediate form of ischemic heart disease indicates the necessity instituting adequate pathogenetic treatment and prophylaxis of hypertensive conditions, normalization of the coronary blood circulation, increase of the resistance of the myocardium to hypoxia, strengthening of reparative processes in the myocardium, activation of oxidation-reduction processes.

[Morphologic changes of venous autografts before aortocoronary shunt surgery]. / Morfologicheskie izmeneniia autovenoznykh transplantatov pered operatsiei aortokoronarnogo shuntirovaniia.

Morphological methods helped to establish optimal conditions of storing venous autotransplants and their preparation to transplantation before the operation of aortocoronary shunting.

[Morphogenetic characteristics of pneumonia in ischemic heart disease]. / Morfogeneticheskie osobennosti pnevmonii pri ishemicheskoi bolezni serdtsa.

It was established by histochemical and immunomorphological investigations that acute myocardial infarction results in an activation of the immune system of the body, immunomorphological changes in the lungs that plays a certain role in the pathogenesis of pneumonias in ischemic heart disease.

[Complex cytomorphological determination of the degree of anaplasia of breast cancer cells]. / Kompleksnoe tsitomorfologicheskoe opredelenie stepeni anaplazii opukholevykh kletok raka molochnoi zhelezy.

Complex study of cytological, morphometric and cytogenetic indices of mammary carcinoma in 92 women and an evaluation of survival of 196 patients depending on the level of tumour anaplasia. The correlation is shown between the tumour anaplasia signs including an interphase nuclei morphometry, X-chromatin content and mitotic index on the one hand and the degree of clinical malignancy confirmed by the results of 5-years survival on the other.

[Mitotic regime in human neoplasms of the stomach, corpus uteri, breast and skin]. / Issledovanie mitoticheskogo rezhima v novoobrazovaniiakh zheludka, tela matki, molochnoi zhelezy i kozhi cheloveka.

The mitotic regime in 362 human tumours of different genesis was studied by the same technique. The data obtained were compared with the histological structure of the tumours and the degree of thier anaplasia. Significance of the observed changes in the mitotic regime for the differential diagnostics of benign and malignant processes and for a complex estimation of biological characteristics of neoplasms is discussed.