RESUMO
We report a rare case of perforated jejunal diverticulitis after an unrelated surgery. A 60-year-old male presented with severe abdominal pain one day after robot-assisted radical prostatectomy. This was diagnosed as perforated jejunal diverticulitis and managed via immediate partial jejunal resection. Key points are as follows. First, surgery may have indirect impacts on diverticulitis perforation because of postoperative intestinal hypomobility and immunosuppression. Second, the diagnosis becomes harder when the perforation occurs after surgery because postoperative laboratory and imaging findings are similar to those after jejunum perforation. Hence, aggressive diagnostic evaluation and immediate treatment are crucial for improving prognosis.
RESUMO
Fourteen cassane-type diterpenoids, echinalides H-U, were isolated from the stem of Caesalpinia echinata Lam. (Leguminosae). The structures of the echinalides were elucidated by spectroscopic investigation, including 2D NMR spectroscopic analysis. The structures of echinalide H and echinalide T were further confirmed by single-crystal X-ray diffraction. The absolute configurations of echinalides H, I, J and K were determined by CD spectroscopy. Additionally, the absolute configurations of echinalide L and M were determined by chemical conversion from echinalide H. These compounds were evaluated for inhibitory activity against nuclear factor κB (NF-κB). Echinalide M showed the most potent inhibitory activity (47±11% at 5µM) toward NF-κB-responsive gene expression.
Assuntos
Caesalpinia/química , Diterpenos/isolamento & purificação , Diterpenos/farmacologia , NF-kappa B/antagonistas & inibidores , Brasil , Cristalografia por Raios X , Diterpenos/química , Células HeLa , Humanos , Proteínas I-kappa B , Conformação Molecular , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Caules de Planta/química , Sementes/química , Transdução de Sinais/efeitos dos fármacosRESUMO
Seven new cassane-type diterpenoids, echinalides A-G (1-7), were isolated from the stem of Caesalpinia echinata LAM. (Leguminosae). The structures were established on the basis of their chemical properties and spectroscopic evidence, including two dimensional (2D)-NMR analysis. These compounds were assessed for inhibitory activity against nuclear factor κB (NF-κB). Echinalides C and D, in particular, significantly inhibited NF-κB-responsive reporter gene expression at 5.0 µM, an effect almost equivalent to that of parthenolide, a known potent inhibitor of NF-κB.
