1.
Org Lett
; 17(11): 2570-3, 2015 Jun 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26010812
RESUMO
A convergent synthesis of the ABC ring of antitumor natural product paclitaxel (Taxol) is described. SmI2-mediated reductive cyclization of an allylic benzoate possessing an aldehyde function, synthesized from tri-O-acetyl-d-glucal and 1,3-cyclohexanedione, smoothly afforded the highly strained 6-8-6 tricarbocyclic structure in 66% yield.