[Effect of carbon dioxide on peroxynitrite reaction with DNA]. / Deistvie dvuokisi ugleroda na reaktsiiu peroksinitrita s DNK.

Carbon dioxide has been reported to react with peroxynitrite (ONO2CO2-), altering the reactivity characteristic of peroxynitrite. We found that carbon dioxide caused a dose-dependent increase in 8-nitroguanine formation in calf thymus DNA incubated with peroxynitrite, whereas there was not apparent effect on 8-oxoguanine formation. In contrast, carbon dioxide inhibited peroxynitrite-induced strand breakage in plasmid pBR322 DNA and thymine-propenal formation from thymidine.