RESUMO
The comparative bioinformatic analysis of psoriasis and Crohn disease pathological processes was carried out using the results of microarray experiments deposited in GEO DataSets database. Several common for both pathologies genes and molecular-genetical processes were found. It is suggested that some transcriptional factors including AP-1 system of transcriptional factors are involved in pathological processes both under psoriasis and Crohn disease.
Assuntos
Cromossomos Humanos/genética , Doença de Crohn/genética , Bases de Dados Genéticas , Fator de Transcrição AP-1/genética , Doença de Crohn/fisiopatologia , Humanos , PsoríaseRESUMO
Psoriasis was used as a model to analyze the pathogenetic pathways of immune-mediated inflammatory diseases, and the results of bioinformatic, molecular-genetic and proteomic studies are provided. Cell mechanisms, common for the pathogenesis of psoriasis, as well as Crohn's disease, are identified. New approaches for immune-mediated diseases are discussed.
