[Estimation of antihypertension efficiency and use of fixed combination perindopril+amlodipin by uncontrollable hypertension patients within the limits of routine treatment].

The results of observational investigation by prescription of the fixed combination perindopril + amlodipin produced by to the uncontrollable hypertension patients by the previous therapy are described in the given article. In Kazan population 50 patients at the age of 32 to 92 with essential hypertension having blood pressure level of 140/90 mm/hg. Were included into the investigation. Before these patients took different groups of antihypertension preparation (including perindopril). The preparation was prescribed in different fixed dosage depending on duration of hypertension, quantity of taken hypertension groups of preparations and blood pressure level. Then during 1, 2, 3 months of treatment the physician had the possibility to determine the dosage necessary to prescribe. The prescription of perindopril in combination with amlodipin during 3 months led to certain lowering of systolic and diastolic arterial pressure for 38.2 and 11.6 mm/hg accordingly and 80% of patients had the required pressure level of (<140/90 mm/hg). Moreover, the frequency of heart beat reduced and necessary increase of patient compliance for treatment took place. Taking the preparation only 31% of patients had unwilling effects but it didnt require the abolition of the antihypertension therapy till the end of observation. As a result, the investigation confirmed the high efficiency, good perception, improvement of patient compliance for treatment by prescribing the fixed combination perindopril + amlodipin.

[Beta-adrenoblockers for the correction of arterial hypertension in postmenopausal women].

The use of beta-blockers is an important component of therapy of cardiovascular pathology (e.g. coronary heart disease, arterial hypertension) in menopausal women. Comparative data on the efficiency of lokren and carvedilol for the correction of grade 2 AH are presented.

[Autonomic nervous system function and effects of beta-adrenoblockers on heart rhythm variability in patients with myocardial infarction]. / Funktsional'noe sostoianie vegatativnoi nervnoi sistemy i vliianie beta-adrenoblokatorov na variabel'nost' ritma serdtsa u bol'nykh infarktom miokarda.

Heart rhythm variability on myocardial infarction (MI) day 1, 3, 7 and 11 was assessed mathematically to study function of the autonomic nervous system in 101 MI patients. The initial autonomic tonicity (IAT), autonomic reactivity (AR) and autonomic maintenance (AM) were studied. Depending on the site of the infarction in the myocardium, different type of autonomic homeostasis were identified. Moderate sympathicotonia, sympathicotonic type of AR and adequate AM irrespective of IM location were found most favourable in relation to the MI course and prognosis. The spectral analysis of the heart rhythm showed a significant shift of the frequency spectrum in the inferior MI to high frequencies and in anterior MI--to low frequencies. Autonomic dysfunction score is higher in the anterior MI. Psychoemotional state of the patients was determined by Spilberg-Khanin test evaluating reactive and personality anxieties. These characteristics were moderate and high in patients with MI and effort angina, respectively. The study of selective beta-adrenoblockers effect on heart rhythm variability proved that lokren (betaxolol) in a dose of 10 mg/day significantly and positively influences heart rhythm and objective status of the patients. Less effective is betacard (atenolol). Nebivolol is not indicated in acute MI. Significant correlations are found between the findings of IAT mathematical analysis, psychoemotional features of the patients and complications of MI. Parameters of an unfavourable course and outcome of MI are described.