RESUMO
The behavior of a series of 3-amino-2-oxazolidinone derivatives with a potential hypnotic activity on achiral (octadecylsilane) and chiral (cellulose tris(4-methylbenzoate)) stationary phases was examined. The compounds differed in the composition of a substituted aromatic ring containing different substituents in different positions. It was possible to resolve all the compounds with selectivity 1.11 < or = alpha < or = 2.74. The enantiodifferentiating power of substituents was correlated to their electron donating ability and position in the aromatic ring.
Assuntos
Benzoatos/química , Celulose/química , Oxazolidinonas/química , Psicotrópicos/química , Celulose/análogos & derivados , Cromatografia Líquida de Alta Pressão , Cinética , Inibidores da Monoaminoxidase/química , Inibidores da Monoaminoxidase/farmacologia , Oxazolidinonas/farmacologia , Psicotrópicos/farmacologia , Estereoisomerismo , Especificidade por SubstratoRESUMO
The influence of 3-amino-2-oxazolidinone derivatives 1-9 on dopaminergic and serotoninergic neurotransmission was tested. It was found that all tested compounds exhibited modulating activity on one (or both) of the neurotransmissions, the effect being dependent on the aromatic ring substituent.
