[Experimental comparative evaluation of the functional capacities of ectopically grown fetal organs].

The interest for fetal organ, tissue, and cell implantation as therapeutic means in the treatment of some diseases is presently increasing. Hence, the aim of the present investigation was the comparative evaluation of the functional potential of ectopically grown fetal organs of different (ecto-, meso- and endodermic) origins. Unified operative model was the fetal organ fragment implantation into an ear subcutaneous pouch (without restoration of vascular and nervous links of the implant with the recipient organism). The implant isolation in vitro varied from 15 to 50 min. As control, intact animals and animals with streptozotocin diabetes and hepatic lesions due to the main bile duct ligature, were used. The implanted and ectopically grown fetal organs, though of different origins, developed functional activity. The best adult-like function was obtained in intestinal, gastric and cardiac implants, i.e. in organs with a cavity and a well developed self-regulation system. Poorer results were obtained in great digestive glandular implants--pancreas and liver. In the best cases when the implant function was very closed to the adult organ, a difference nevertheless was observed. The model of ectopic implantation of fetal organs may be useful for study of the organ and tissue function ontogenesis (up to the moment of natural ageing involution), for the evaluation of different isolated factor influence on organ and tissue physiology and pathology. Although being optimistic in respect to clinical application of fetal organ and cell implantation, this study does not prevent us from being cautions.

[The transplantation to adult animals of the pancreas from fetuses]. / Peresadka vzroslym zhivotnym podzheludochnoi zhelezy plodov.

The possibility of using the syngeneic and allogeneic foetal pancreas implantation was shown for therapy of diabetes mellitus. Cases of the implantation with no immunosuppression were studied in 57 patients.

[The transplantation to adult animals of fetal small intestine]. / Peresadka vzroslym zhivotnym tonkoi kishki plodov.

Use of the ectopic growth (culture) of foetal small intestine in vivo as a model for study of normal and pathological development of an organ or its different structures was shown to be possible. Complete structural and functional development of foetal small intestine was reached under certain conditions of its implantation.