RESUMO
Two new xanthones, pyranocycloartobiloxanthone A (1) and dihydroartoindonesianin C (2), were isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation. Their structures were determined by using spectroscopic methods and comparison with known related compounds. Pyranocycloartobiloxanthone A (1) showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines.
Assuntos
Artocarpus/química , Sequestradores de Radicais Livres/isolamento & purificação , Plantas Medicinais/química , Xantonas/isolamento & purificação , Compostos de Bifenilo/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Sequestradores de Radicais Livres/química , Sequestradores de Radicais Livres/farmacologia , Malásia , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Picratos/farmacologia , Casca de Planta/química , Xantonas/química , Xantonas/farmacologiaRESUMO
A new coumarin, 8,4''-dihydroxy-3'',4''-dihydrocapnolactone-2',3'-diol (1) and two known triterpenes, 5(6)-gluten-3-one (2) and 5(6)-gluten-3alpha-ol (3) were isolated from the leaves of Micromelum minutum (Rutaceae) collected from Sepilok, Sabah, Malaysia and their structures were characterized by spectroscopic methods.
Assuntos
Cumarínicos/isolamento & purificação , Rutaceae/química , Triterpenos/isolamento & purificação , Cumarínicos/química , Espectroscopia de Ressonância Magnética , Malásia , Estrutura Molecular , Triterpenos/químicaRESUMO
In a continuation of our study of the Rutaceae, detailed chemical investigation on Micromelum minutum (Rutaceae) collected from Sepilok, Sabah, Malaysia gave four new coumarins. The structures of the coumarins have been fully characterised by spectroscopic methods as 3",4"-dihydrocapnolactone 1, 2',3'-epoxyisocapnolactone 2, 8-hydroxyisocapnolactone-2',3'-diol 3 and 8-hydroxy-3",4"-dihydrocapnolactone-2',3'-diol 4.
