Prevalence and pattern of knee osteoarthritis among nurses

Nurses at work assume uncomfortable postures that predispose the knee joint to osteoarthritis (OA) due to excess workload and stress. This study determined the prevalence and pattern of knee OAamong nurses. This cross - sectional designed survey employed convenient sampling technique to enrol 300 eligible and volunteer nurses from three randomly selected public hospitals out of five existing ones located at the study area. Written informed consent forms were issued to eligible participants. Forms containing socio-demographic variables and physical characteristics of the participants, American College of Rheumatology (ACR) clinical classification criteria for diagnosis of symptomatic knee OA, and health seeking behaviour were administered on the participants. Descriptive and Chi square (X2) statistics were employed to summarize and analyze the collected data respectively. Mean age and age range in years of the participants were 39.92 ± 10.97 and 19-65 respectively. Prevalence of knee OA among the nurses was 32.3%. Significant differences (p < 0.05) in the prevalence of knee OAamong the participants existed in the following variables: age groups, body mass indices (BMI), rank and years of working experience. Most (62.9%) participants presented with unilateral knee OA. Prevalence of knee OAamong nurses at the public hospitals surveyed was 32.3%. Age, BMI, working experience and rank were significantly associated with knee OA

Efficacy, safety and tolerability of artesunate-mefloquine in the treatment of uncomplicated Plasmodium falciparum malaria in four geographic zones of Nigeria.

BACKGROUND: The combination of artesunate and mefloquine has been reported to be effective against multi-drug resistant Plasmodium falciparum malaria, which has been reported in Nigeria. The objective of this multi-centre study was to evaluate the efficacy, safety and tolerability of the co-packaged formulation of artesunate and mefloquine in the treatment of uncomplicated malaria in two weight groups: those between 15 - 29 kg and > or = 30 kg respectively. METHODS: The trial was conducted in rural communities in the north-east, north-central, south-west and south-eastern parts of Nigeria. The WHO protocol for testing antimalarial drugs was followed. Outpatients having amongst other criteria, parasite density of > or =1,000 microl were enrolled. The co-packaged drugs were administered for 3 days at a dosage of artesunate, 4 mg/kg body wt/day and mefloquine, 25 mg/kg/body wt total) on days 0, 1 and 2. Patients were followed up for 28 days with the assessment of the parasitological parameters on days 1, 2, 3, 7, and 28. RESULTS: Four hundred and forty-six (446) patients were enrolled and 431 completed the study. Cure rates in both treatment groups was >90% at day 28. The mean parasite clearance times in treatment groups I and II were 40.1 and 42.4 hours respectively. The combination of artesunate and mefloquine showed good gametocidal activity, (gametocyte clearance time of 42.0 & 45.6 hours in treatment groups I and II respectively). There were no serious adverse events. Other adverse events observed were headache, dizziness, vomiting and abdominal discomfort. There was no significant derangement in the haematological and biochemical parameters. CONCLUSION: This co-packaged formulation of artesunate + mefloquine (Artequin) is highly efficacious, safe and well-tolerated. It is recommended for the treatment of uncomplicated P. falciparum malaria in Nigeria.