RESUMO
The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Some studies have reported that HLA class II genes play a strong role in severe cases of pulmonary tuberculosis (PTB) in several populations. Thus the aim of the study was to compare the HLA-class II alleles of patients with drug resistant tuberculosis with those of healthy controls from the same ethnic group in Kazakhstan. The aim of the present study was to evaluate the correlation of HLA-class II alleles by patients with drug resistant tuberculosis and the healthy controls of the same ethnic group in Kazakhstan. The HLA-class II alleles of 76 patients with tuberculosis (TB) and 157 healthy volunteers were investigated using sequence-based typing (SBT)-method. HLA-DQA1*03:02 HLA-DRB1*08:01 and DRB1*08:03 occurred more frequently (P = 0.05) in patients with drug resistant tuberculosis than in controls. We observed a possible association between certain HLA alleles and TB that are specific for the Kazakh population. Further studies are needed to confirm our findings using a larger number of patients with drug resistant tuberculosis.
Assuntos
Predisposição Genética para Doença , Cadeias alfa de HLA-DQ/genética , Cadeias HLA-DRB1/genética , Haplótipos , Tuberculose Resistente a Múltiplos Medicamentos/genética , Tuberculose Pulmonar/genética , Adulto , Antituberculosos/uso terapêutico , Estudos de Casos e Controles , Feminino , Frequência do Gene , Cadeias alfa de HLA-DQ/classificação , Cadeias alfa de HLA-DQ/imunologia , Cadeias HLA-DRB1/classificação , Cadeias HLA-DRB1/imunologia , Teste de Histocompatibilidade , Humanos , Cazaquistão , Masculino , Pessoa de Meia-Idade , Mycobacterium tuberculosis/efeitos dos fármacos , Mycobacterium tuberculosis/imunologia , Tuberculose Resistente a Múltiplos Medicamentos/tratamento farmacológico , Tuberculose Resistente a Múltiplos Medicamentos/imunologia , Tuberculose Resistente a Múltiplos Medicamentos/microbiologia , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/imunologia , Tuberculose Pulmonar/microbiologiaRESUMO
The author analyzed the outcomes of treatment of 88 patients with various types of pulmonary tuberculosis, of them 44 (Group 1) were diagnosed as having tuberculosis of the large bronchi (TLB) by bronchoscopy and verified by cytological of morphological studies of biopsy specimens and the other 44 (Group 2) had intact bronchi. TLB occurred in all age groups and in various types of the pulmonary tuberculosis. This complication occurred at the patients" late referral and in the presence of other complications and concomitant diseases. The patients with TLB were found to have slow rates of abacillation and decay cavity closure in the lung, which required more prolonged treatment.
Assuntos
Broncopatias/complicações , Tuberculose Pulmonar/complicações , Adolescente , Adulto , Idoso , Antituberculosos/uso terapêutico , Biópsia , Brônquios/microbiologia , Broncopatias/diagnóstico , Broncopatias/tratamento farmacológico , Broncoscopia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/tratamento farmacológicoRESUMO
Tuberculosis of the large bronchi (TLB) was diagnosed by rigid bronchoscopy (RBS) in 9.4% and by fibrobronchoscopy (FBS) in 18.3% of patients. Such great differences are attributable to the extension of a visualization area during FBS than during RBS. Analyzing the specimens obtained at bronchoalveolar lavage and other types of biopsy of TLB areas cytologically and histologically confirmed the visual picture in 63.4% of cases.
