RESUMO
Immunomodulating properties of ceruloplasmin were determined in vivo on healthy mice line C57BL/6 and mice with Lewis carcinoma. It was established, that ceruloplasmin at the concentration of 1-40 mg/kg stimulated both T- and B--systems of immunity and prevented immunodepression activity of tumor growth.
Assuntos
Adjuvantes Imunológicos/farmacologia , Ceruloplasmina/farmacologia , Neoplasias Pulmonares/imunologia , Neoplasias Experimentais/imunologia , Animais , Linfócitos B/imunologia , Concanavalina A/farmacologia , Ativação Linfocitária , Camundongos , Camundongos Endogâmicos C57BL , Linfócitos T/imunologia , Células Tumorais Cultivadas/imunologiaRESUMO
The influence of ceruloplasmin on the development of delayed hypersensitivity (DHS) and activity of T-suppressors were studied in experiments on intact Balb/c mice. Ceruloplasmin introduced in a dose of 5 mg per 1 kg of weight a day before immunization of animals is shown to have a stimulating effect. The amount of the introduced drug being raised to 200 mg per 1 kg of weight suppressed the ability of organism to form DHS effect rather than increased it. Ceruloplasmin is stated to inhibit induction of DHS suppressors and to exert no effect on the expression of functional activity of the formed suppressors.
Assuntos
Adjuvantes Imunológicos , Ceruloplasmina/farmacologia , Hipersensibilidade Tardia/etiologia , Animais , Relação Dose-Resposta a Droga , Hipersensibilidade Tardia/imunologia , Imunização Passiva/métodos , Camundongos , Camundongos Endogâmicos BALB C , Linfócitos T Reguladores/efeitos dos fármacos , Linfócitos T Reguladores/imunologiaRESUMO
Total content and individual fractions of polyamines were studied in lymphocytes of thymus and spleen tissues as well as in lymphatic glands of mice with Lewis carcinoma (strain C57BL/6). Fraction composition as well as total content of polyamines were altered during malignization, as a result of which proliferative activity of lymphocytes was shifted.
Assuntos
Linfócitos/metabolismo , Neoplasias Experimentais/metabolismo , Espermidina/metabolismo , Espermina/metabolismo , Animais , Sistema Linfático/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Baço/metabolismo , Timo/metabolismoAssuntos
Anticorpos Monoclonais/análise , Anticorpos Antivirais/análise , Antígenos Virais/imunologia , Epitopos/imunologia , Hemaglutininas Virais/imunologia , Vírus da Influenza A Subtipo H2N2 , Vírus da Influenza A/imunologia , Receptores Virais/imunologia , Adsorção , Animais , Anticorpos Monoclonais/isolamento & purificação , Anticorpos Antivirais/isolamento & purificação , Especificidade de Anticorpos , Embrião de Galinha , Imunização , Testes de Neutralização , CoelhosRESUMO
A comparative immunological analysis of the antigenic structure of hemagglutinins of influenza H2N2 viruses isolated in 1957-1967 was carried out by the method of specific adsorption of highly active antiviral rabbit sera. The hemagglutinins of the viruses under study were shown to contain at least three antigenic determinants changing in the course of evolution, one of them shared by all the viruses of the H2N2 subtype remaining antigenically stable since 1957 until 1967.
