1.
Chem Asian J
; 17(10): e202200142, 2022 May 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35338588
RESUMO
Here, we describe the design and synthesis of a new reduction-cleavable spacer (RCS) based on a nitrobenzene scaffold for constructing reduction-responsive oligonucleotides according to standard phosphoramidite chemistry. In addition, we demonstrate that the introduction of the RCS in the middle of an oligonucleotide (30 nt) enables the construction of a self-assembled microsphere capable of exhibiting a reduction-responsive disassembly.