Risk assessment of chemical release accident triggered by landslide using Bayesian network.

This study evaluated the risk of 461,260,800 scenarios of chemical release accidents triggered by landslides. Several industrial accidents triggered by landslides have recently occurred in Japan; however, only a few studies have analyzed the impact of landslide-triggered chemical release accidents on the surrounding areas. Bayesian networks (BNs) have recently been used in the risk assessment of natural hazardtriggered technological accidents (Natech) to quantify uncertainties and develop methods applicable to multiple scenarios. However, the scope of BN-based quantitative risk assessment is limited to the risk assessment of explosions triggered by earthquakes and lightning. We aimed to extend the BN-based risk analysis methodology and evaluate the risk and the effectiveness of the countermeasures for specific facility. A methodology was developed to assess human health risk in the surrounding areas when n-hexane was released and dispersed into the atmosphere due to a landslide. Risk assessment results showed that the societal risk (representing the relationship between frequency and number of people suffering from a particular harm) of the storage tank closest to the slope exceeded the Netherlands' criteria, which are the safest among the criteria in the United Kingdom, Hong Kong, Denmark, and the Netherlands. Limiting the storage rate reduced the probability of one or more fatalities by up to about 40% compared with the no countermeasure case and was a more effective countermeasure than using oil fences and absorbents. Diagnostic analyses quantitatively showed that the distance between the tank and slope was the main contributing factor. The catch basin parameter contributed to the reduction in the variance of the results compared to the storage rate. This finding indicated that physical measures, such as strengthening or deepening the catch basin, are essential for risk reduction. Our methods can be applied to other natural disasters for multiple scenarios by combining it with other models.

Reducing waste management scenario space for developing countries: A hierarchical clustering on principal components approach.

The complexity of waste management (WM) problems resulted in the explosion of scenarios that challenge focused discussion among stakeholders and hinder the integrity of policy responses in developing countries. Hence, drawing similarities is essential to reduce the number of scenarios to simplify the WM efforts. To extract similarities, measuring WM performance is not enough, but the background factors related to this performance should be incorporated. These factors form a unique system characteristic that facilitates or hinders WM functions. Thus, this study applied multivariate statistical analysis to clarify underlying characteristics that facilitate efficient WM scenario developments for developing countries. The study first analysed drivers associated with improved WM system performance using bivariate correlation analysis. As a result, twelve significant drivers associated with controlled solid waste were identified. Then, it mapped the countries based on their WM system characteristics using the combined principal component analysis and hierarchical clustering approach. Thirteen variables were examined to extract similarities between the countries. The results identified three homogenous clusters. The clusters were found considerably parallel to the global classifications based on income and human development index. Hence, the presented approach is efficient in explaining similarities that reduce WM scenarios and favours cooperation among countries.

CD73-Positive Cell Spheroid Transplantation Attenuates Colonic Atrophy.

The incidence of inflammatory bowel diseases (IBD) is increasing worldwide. Mesenchymal stem/stromal cells (MSCs) have immunomodulatory functions and are a promising source for cell transplantation therapy for IBD. However, owing to their heterogeneous nature, their therapeutic efficacy in colitis is controversial and depends on the delivery route and form of transplanted cells. Cluster of differentiation (CD) 73 is widely expressed in MSCs and used to obtain a homogeneous MSC population. Herein, we determined the optimal method for MSC transplantation using CD73+ cells in a colitis model. mRNA sequencing analysis showed that CD73+ cells exhibited a downregulation of inflammatory gene expression and an upregulation of extracellular matrix-related gene expression. Furthermore, three-dimensional CD73+ cell spheroids showed enhanced engraftment at the injured site through the enteral route, facilitated extracellular matrix remodeling, and downregulated inflammatory gene expression in fibroblasts, leading to the attenuation of colonic atrophy. Therefore, the interaction between intestinal fibroblasts and exogenous MSCs via tissue remodeling is one mechanism that can be exploited for colitis prevention. Our results highlight that the transplantation of homogeneous cell populations with well-characterized properties is beneficial for IBD treatment.

Health risk assessment and cost-benefit analysis of agricultural soil remediation for tailing dam failure in Jinding mining area, SW China.

The impact of the tailing dams and the economic feasibility of the remediation process is significant for future risk management for tailing dams. In this research, we develop a hypothetical failure scenario for a tailing dam in the Jinding mining area, Southwest China. We assess the exposure with the Geo-Environmental Risk Assessment System, tier-1 model, and health impact with Disability-Adjusted Life Years (DALY). Cost and benefit are also analyzed for the following clean-up process. The result shows that the exposure dose (mg/kg-BW/d) of As, Cd, and Pb right after the dam failure is 1.07 × 10-2 for As, 1.76 × 10-4 for Cd, and 5.68 × 10-3 for Pb, respectively. The DALY caused by heavy metal exposure is 2.63 × 10-2 DALY per year, which significantly exceeds the tolerable level. This indicates that the tailing dam failure will pose a high health risk to the residents, and remediation is necessary. After remediation, the DALY is 1.24 × 10-8 DALY per year, indicating the clean-up process effectively reduces the resident's health impact. From the financial point of view, the net present value of the clean-up is $- 1.02 × 107. This indicates that the clean-up process is not economically feasible. Sensitivity analysis shows that the amount of released tailing influences the output result. The time span for benefit estimation is also an important issue. This research shows that the impact of a tailing dam failure will be severe, and remediation may be effective but economically infeasible. Therefore, preventing tailing dam failure is the most crucial task for the local government.

Longitudinal Analyses after COVID-19 Recovery or Prolonged Infection Reveal Unique Immunological Signatures after Repeated Vaccinations.

To develop preventive and therapeutic measures against coronavirus disease 2019, the complete characterization of immune response and sustained immune activation following viral infection and vaccination are critical. However, the mechanisms controlling intrapersonal variation in antibody titers against SARS-CoV-2 antigens remain unclear. To gain further insights, we performed a robust molecular and cellular investigation of immune responses in infected, recovered, and vaccinated individuals. We evaluated the serum levels of 29 cytokines and their correlation with neutralizing antibody titer. We investigated memory B-cell response in patients infected with the original SARS-CoV-2 strain or other variants, and in vaccinated individuals. Longitudinal correlation analyses revealed that post-vaccination neutralizing potential was more strongly associated with various serum cytokine levels in recovered patients than in naïve individuals. We found that IL-10, CCL2, CXCL10, and IL-12p40 are candidate biomarkers of serum-neutralizing antibody titer after the vaccination of recovered individuals. We found a similar distribution of virus-specific antibody gene families in triple-vaccinated individuals and a patient with COVID-19 pneumonia for 1 year. Thus, distinct immune responses occur depending on the viral strain and clinical history, suggesting that therapeutic options should be selected on a case-by-case basis. Candidate biomarkers that correlate with repeated vaccination may support the efficacy and safety evaluation systems of mRNA vaccines and lead to the development of novel vaccine strategies.

Characterizing potential risk triggered by road traffic noise in comparison with typical air pollutants NO2 and PM2.5.

Characterizing multiple risk stemming from automobiles are required from the viewpoint of priority setting for future risk management. However, little is known about such issues given the inadequacy of indicators. In this research, with the illustration of the metropolitan city of Osaka, Japan, using disability-adjusted life years (DALYs), impacts of road traffic noise and exhausts gas (nitrogen dioxide (NO2) and particulate matter (PM2.5)) were quantified and compared with the risks of ischemic heart disease and high sleep disturbance; and respiratory disease as endpoints, respectively. Health risks due to automobile noise were 3102.1 and 97.8 DALYs under the condition of open and closed windows, respectively. The health risks were reduced by 96.8% under closed-window condition. On the other hand, the health risks caused by NO2 and PM2.5 from automobiles were 137.6 DALYs, which was lower than the health risks due to automobile noise. These results indicate the effectiveness of DALYs as an indicator to characterize different kinds of burden of health and environmental impacts from automobiles, and they were successfully used to evaluate the effectiveness of risk reduction options such as the difference between open and closed windows. Furthermore, most people were found to have been exposed to 55-60 dB noise level. Although they easily get used to and can tolerate this level, it is also the stage at which health risks begin to occur. Therefore, with continuous exposure, qualitative estimation showed that open windows under this noise level subsequently leads to high potential health risks.

Origin and migration of trace elements in the surface sediments of Majuro Atoll, Marshall Islands.

The sediments of Majuro Atoll, Marshall Islands, consist of bioclastic materials, including foraminifera and coral debris. The sedimentary depth profiles of elements showed that various elements including zinc (Zn) and copper (Cu) were enriched in the upper layers of the islands of Majuro Atoll. Carbon-14 dating revealed that the sedimentation of the upper layer was completed before 1670 and 542 cal BP in Laura and Calalen, respectively. The enriched elements could be categorized by their origins: (a) terrestrial elements transported as dust (aluminum (Al) and rare earth elements (REEs)); (b) anthropogenic elements (Zn and Cu); and (c) elements supplied by seabirds (phosphorus (P)). From the results of the total amount of Al supplied to sediments for ca. 2000 years, Al in Majuro Atoll was suggested to be airborne origin. The enrichment factors of the elements normalized to Al concentration of continental crust showed that REEs were also transported as dust, while Zn and Cu were mainly of anthropogenic origin. The speciation analysis by X-ray absorption near-edge structure (XANES) showed the presence of Zn-Cu alloys originated from industrial products. It was also revealed that Zn was enriched in the surface due to anthropogenic emission after urbanization on Majuro Atoll and fixed by carbonate and phosphate at the upper layer, which inhibits migration of Zn into the deeper layer and its release to the groundwater and costal water. Hence, the fixation of heavy metals at the surface prevents their exposure to aquatic organisms and residents via fresh groundwater in the island.