[Malignant mesothelioma of the peritoneum]. / Zlokachestvennaia mesotelioma briushiny.

An observation of malignant peritoneal mesothelioma in a man of 61 is presented. The clinical signs included fatigue, loss of weight, enlarged abdomen. The duration of the disease was 8 months. The autopsy revealed a whitish tumor of the peritoneum of cartilage density with numerous nodules 0.5-1.5 cm in diameter. The tumor overgrew the liver, spleen, pancreatic gland, stomach, and intestinal loops forming a single conglomerate. In the peritoneal cavity there were 4000 ml of transparent yellowish fluid. The visceral and parietal pleura on the left was thicker and covered with small whitish nodules. Histological examinations showed the peritoneum to be thickened, sclerosed and hyalinized. In the thickness of the fibrous stroma there were numerous slits lined with mesothelial cells. There were metastases in regional lymph nodes. The tumor had the structure of a malignant mesothelioma of the epithelial-like variant.

[Myocardial morphology in fibrillation and defibrillation of the heart ventricles]. / Morfologiia miokarda pri fibrilliatsii i defibrilliatsii zheludochkov serdtsa.

The morphology of the contractile myocardium was studied experimentally in fibrillation and defibrillation of the ventricles on 30 rabbits. Morphology of the contractile myocardium appears as vacuolated dystrophy of the cardiomyocytes, destruction of mitochondria and contracture lesions of the myofibrils. The latter with progressing fibrillation become irreversible. Myocardial changes are related both to the mechanical lesions of cardiomyocytes and the haemodynamic disorders, developing as a result of ventricular fibrillation, which leads to marked myocardial hypoxia. The changes in the microcirculatory bed contribute to the development of the latter. Hyperfunction of the intracellular structures, especially of mitochondria and myofibrils, taking place under unfavourable conditions leads to a rapid energy depletion, which is one of the main causes of development of the acute cardiac insufficiency in this type of arrhythmias. Studies of cardiac defibrillation enabled one to elicit the dynamics of morphological changes, appearing in the myocardium as related to the duration of ventricular fibrillation.

[Changes in the contractile myocardium in acute rhythm disorders]. / Izmeneniia sokratitel'nogo miokarda pri ostrykh narusheniiakh serdechnogo ritma.

Experiments in rabbits were carried out to study the morphology of contractile myocardium in arrhythmias caused by electric stimulation of previously intact myocardium (1st group) and in those caused by inhalation of ammonia steam against the background of exogenous poisoning with barium chloride (2nd group). Morphological lesions of contractile myocardium consisting in granular an vacuolar dystrophy at 1--3 days of the experiment and focal myocytolysis at 7 days were demonstrated. In animals of the 2nd group, morphological lesions in the myocardium were more severe and by the 7th day of the experiment included both focal myocytolysis and contracture alterations. Changes in the blood vessels of the microcirculation bed were similar in both groups consisting of vascular spasm followed by paresis, plethora, diapedetic hemorrhages and early signs of thrombus formation. The latter was observed earlier in animals of the 2nd group. The observed morphological changes in contractile myocardium may be regarded as one of the forms on non-coronarogenic myocardiopathies.

[Use of phosphaden in treating chronic ischemic heart disease]. / Primenenie fosfadena pri lechenii bol'nykh khronicheskoi ishemicheskoi bolezn'iu serdtsa.

The pharmacodynamics and pharmacotherapy of phosphaden (adenosine-5-monophosphate), a Soviet activator of energy metabolism, were studied in patients with chronic ischemic heart disease. Functional and biochemical methods were used. It was established that phosphaden is an effective drug in the treatment of chronic ischemic heart disease. The results of clinical, functional and biochemical examination support this conclusion.