[Development and assessment of efficacy of L-polylactide matrix for creation of a tissue-engineered vascular graft]. / Razrabotka i otsenka éffektivnosti matritsy iz L-polilaktida dlia sozdaniia tkaneinzhenernogo sosudistogo implantata.

In order to create a tissue-engineered vascular graft we elaborated a matrix consisting of nanofibres of biodegradable polymer L-polylactide. We worked out the methodology of crystallization of the matrix on a rod, making it possible to manufacture specimens possessing strength and deformity characteristics superior to those of native vessels. This was followed by a series of chronic experiments on implanting the elaborated matrix into the abdominal aorta of rats for the duration of up to 16 months. We obtained satisfactory parameters of the patency of the matrices (71%). According to the findings of histological examination, in the course of time there occurred biodegradation of the matrix and formation of a new vascular wall, with no evidence of either inflammation or neointimal hyperplasia in the zone of the anastomoses. Resorption of the polymeric fibres commenced 12 weeks after exposure and completely terminated after 64 weeks. By that time, both neointima and neoadventitia were formed, whose composition and structure were close to those of the native vessel. Insufficiently high mechanical properties of the zone of reconstruction turned out to be the cause of the formation of aneurysms.

[Medical rehabilitation in the Armed Forces: history, current state and prospects].

Authors analyzed history, current state and prospects of medical rehabilitation in the Armed Forces of the Russian Federation. Current system of medical rehabilitation in the Armed Forces provides all categories of military personnel and members of their families complete rehabilitative and remedial measures. An integration of rehabilitative experience of the medical service of the Armed Forces of the Russian Federation into the State system of medical rehabilitation, active participation of the medical service of the Armed Forces of the Russian Federation in activity of National association of specialists of medical rehabilitation and regenerative medicine will allow to increase the effectiveness of the rehabilitation system of the Armed Forces.

[Main ways of improvements of the systems of medical rehabilitation of military servicemen after cardiovascular surgery].

For better improvement of medical rehabilitation referred to effective restoration of functional status of servicemen after cardiovascular surgery it is necessary to introduce standards of medical rehabilitation at all stages of rehabilitation, syndrome-pathologic principle of grouping patients, multidisciplinary organisation of medical activity: cardiologist-physician, specialist of functional diagnostics, specialist of physical therapy, psychotherapist, physical therapeutic, surgeon and specialist of professional rehabilitation. Basic ways of improvement of the system of rehabilitation were organisational technologies of interaction during early and late stages of rehabilitation and persistent control of quality and effectiveness of rehabilitation. Optimization of organisation of late stage of hospitalisation allowed to reduce the average time of rehabilitation to 33,3% and at the same time to improve effectiveness of rehabilitation.

[Branch No. 2 of the Vishnevskiy Central Military Clinical Hospital No. 3 celebrates the 25th anniversary].

Authors present a short summary about the history of 6th Central Military Clinical Hospital (now - Branch N 2 of the Vishnevskiy Central Military Clinical hospital N3), founded in September 1989. Hospital Branch N 2 is one of the first specialized applied research centres in our country, many highly-qualified, experienced and certified professional work at the hospital; they are proficient in original and unique methods of treatment based on high technologies and capable to solve any problem, even the most difficult, connected with medical rehabilitation of patients. Hospital Branch N 2 is also known as the Centre of orthopaedic and prosthetic aid to disabled servicemen. Also patients with different diseases and suffering from boardline mental disorders, psychosomatic disorders and chronic fatigue syndrome receive complete rehabilitative therapy under "late" hospital stage.

[Development of the rehabilitation system for wounded during the late hospital stage].

The current article deals with the main methods of development of the rehabilitation system for wounded during the late hospital stage. The problems of specialized rehabilitation for injured, patients of cardiology and neurology and the application of the newest rehabilitation techniques used to optimize medical aid in order to promote professional qualities recovery experience are also considered.

[Erectile dysfunction: choice of the treatment method].

The 15-year clinical experience with falloendoprosthetic operations (FEPO) in patients with erectile dysfunction is reviewed including algorithm of diagnostic examination, prostheses of different generations, indications and contraindications for falloendoprosthetic surgery. The results of 117 FEPO are outlined with special emphasis on 19 cases of postoperative complications. The conclusion is made that FEPO is most effective in erectile dysfunction by the presented criteria of the erectile dysfunction treatment efficacy.

[Peculiarities of mental disorders and evaluation of life quality in military personnel wounded in local military conflicts].

The goal of research is the study of the peculiarities of clinico- psychopathologic varients of development of mental disorders and life quality in military personnel, wounded in local military conflicts in conditions of multidisciplinary military hospital. 317 patients aged 19-45 with mine-explosive wounds got in the Chechen Republic and Dagestan were examined. Analysis performed in early and secondary post stress period showed the predominance of border-line psychopathologic disorders and detected some peculiarities.

[Composite materials based on chitosan and montmorillonite: prospects for use as a matrix for stem and regenerative cell cultivation].

This paper examines the structural and mechanical properties of composite materials based on chitosan and micro- and nanoparticles of Na-montmorillonite and possibility of application for cultivation and targeted delivery of mesenchymal stem cells and regenerative cells. It's have been shown by addition of Na-montmorillonite biomaterial acquires stability of structural and mechanical properties in the sterilization process the handling of liquid media in cell culture. In vitro studies using dermal fibroblasts and adipose tissue mesenchymal stem cells demonstrated that this material has a set of properties to ensure matrix biocompatibility.

[System of rehabilitation in the Armed Forces: history, current situation, and perspectives of development].

There are two main directions of development of medical rehabilitation in the Armed Forces of RF for now-days: medical-psychological rehabilitation of military service men among special contingents, realizing special military duty (air- and NAVY-staff, staff duty shift of Missile Force of Special Purpose) and medical rehabilitation of military service men, participants of battle action in accordance with sub-program "Social support and rehabilitation of invalids in consequence of battle action or battle trauma" of Federal Purpose Program in the sphere of social support of invalids. The authors mark necessity of reorientation of medical strategy from evaluation of determination of symptoms of already existent disease to evaluation of determination of adaptation reserves of organism of military service men, determination of changes in organism on the stage of pre-disease.