[Correlated connection of endocrine function of thymus and other internal secretion glands at stages of developing uterine choriocarcinoma]. / Korreliatsionnye sviazi éndokrinnoi funktsii timusa i drugikh zhelez vnutrennei sekretsii na étapakh razvitiia khoriokartsinomy matki.

The mechanisms of endocrine and immune system disorders in normal and disturbed pregnancy as well as in chorionocarcinoma, hydatid mole, metastatic and non-metastatic chorionocarcinoma have been investigated. Relevant disorders were chiefly caused by the endocrine function of the thymus and gonadotropins from the trophoblast, which made a powerful impact on the periphery of hormonal and immunological homeostasis. Unlike normal pregnancy, gestational trophoblastic disease involved changes in the nature, direction and degree of correlations between endocrine formations, which in turn determined the pathogenetic pattern of the disease.

[The level of embryonic antigens in the blood serum and cerebrospinal fluid of neuro-oncological patients]. / Soderzhanie émbrional'nykh antigenov v syvorotke krovi i likvore neiroonkologicheskikh bol'nykh.

The levels of embryonic antigens (cancer embryonic antigen, alpha-fetoprotein, beta-chorionic gonadotropin were measured in the serum, spinal fluid, the cystic fluid of tumor 83 of neuro-oncological patients. It was found that the blood concentrations of cancer embryonic antigen and alpha-fetoprotein were not generally related to the degree of malignancy and the blood level of beta-chorionic gonadotropin decreased with the higher degree of tumor anaplasia. The high content of beta-chorionic gonadotropin in the spinal fluid suggests its origin from a brain tumor. The fatal postoperative outcome was noted in patients having high preoperative serum levels of alpha-fetoprotein and cancer embryonic antigen with simultaneous much higher concentrations of alpha-fetoprotein in the serum than those in the spinal fluid.

[The effect of environmental factors on the concentration of tumor markers in the blood serum and on the indices characterizing thyroid function]. / Vliianie nekotorykh faktorov okruzhaiushchwei sredy na kontsentratsiiu v syvorotke krovi opukholevykh markerov i pokazateli, kharakterizuiushchie sostoianie shchitovidnoi zhelezy.

Combined versus separate exposure of male organism to cesium-137 and chemical agents results in a more pronounced hyperferritinemia in the former case. In female chemists the ferritin level is dependent to a considerable extent on the menstrual cycle showing a tendency for the iron-containing protein level to decrease because of the action of a number of chemical agents. The rise of the level of cancer embryonic antigen is more readily seen in persons with high levels of cesium-137. Concentrations of carbohydrate antigen (CA-125) and mucin-like antigen are appreciably higher in female chemists incorporating cesium-137, and in those within the 30-km radius of the ChNPP. The level of thyroglobulin was raised in the chemists having a background incorporation of cesium, the liquidators of the aftermaths, and particularly in those happened to be in the 30-km zone. Each of the unfavourable factors taken separately (chemical agent or cesium-137) had lesser effect on the degree of elevation of TG content and hormone-forming function of the thyroid gland. An additional information has been obtained concerning the risk groups, which, however, serves as an indirect measure of carcinogenic effect various environmental factors exert on the organism.

[Changes in the levels of tumor markers in those working with different chemically active substances]. / Izmenenie urovnei opukholevykh markerov u rabotaiushchikh s razlichnymi khimicheski aktivnymi veshchestvami.

Groups at risk for malignant neoplasia were identified among workmen occupationally exposed to different chemical substances, using immunoradiometric and enzyme immunoassays of tumor-associated antigens. Exposure to the above occupational hazard was found to affect the workmen and cause certain chronic illness accompanied by some increase in concentration of a number of tumoral markers. Increase in tumour antigens suggests indirectly that the chemical substances may have carcinogenic activity. We have every reason to recommend these tests as an additional method for identification of groups at high risk for subsequent development of tumours in the digestive system and reproductive organs of persons occupationally exposed to chemical substances.

[Changes in the neuroendocrine and immune state of adaptational homeostasis in normal pregnancy]. / Izmeneniia v neiroéndokrinnom i immunnom zveníakh adaptatsionnogo gomeostata pri fiziologicheski protekaiushchei beremennosti.

43 women with physiologically proceeding pregnancy have been examined during 1st, 2nd and 3d terms. The control group consists of 28 practically healthy non-pregnant women. It is stated that during pregnancy essential changes in the function of endocrine glands of mother take place. the appearance of placenta, a new gland of internal secretion, producing choriogonadotropin (CG) as well as the great amount of other hormones of the steroid and protein nature causes essential changes in the regulatory mechanisms underlying the physiological activity of internal secretion glands in mother. The development and early functioning of the internal secretion glands of a fetus promote the hormonal shifts. With the pregnancy development the number of estrogen increases hundred times, relative to their production in non-pregnant women secretion of progesterone and prolactin increase ten times. The functional activity of anterior lobe of the hypophysis, manifesting itself in hypersecretion of adrenocorticotropic hormone inhibition of follicule-stimulating hormone production changes as well. Changes in the functional state of the adrenal gland cortex: cortisole secretion is high are found.

[Function of the hypophyseal-ovarian-adrenal system in trophoblastic disease]. / Funktsional'noe sostoianie gipofizarno-ovarial'no-nadpochechnikovoi sistemy pri trofoblasticheskoi bolezni.

Hyperproduction of chorionic gonadotropin was shown to be the first link in the chain of hormonal disturbances involved in trophoblastic disease, which induced changes of pituitary gonadotropic function. Ovarian function is affected by disturbances in trophoblastic and pituitary gonadotropic functions and depends on the extension and severity of the disease. This makes a case for corrective hormonal therapy in chorionepithelioma patients resistant to cytostatic or substitution therapy with sex hormones and in whom ovaries have been removed during combined treatment.

[Diagnostic value of determining chorionic gonadotropin and trophoblastic beta 1-glycoprotein in trophoblastic disease]. / O diagnosticheskoi tsennosti opredeleniia khorionicheskogo gonadotropina i trofoblasticheskogo beta 1-glikoproteina pri trofoblasticheskoi bolezni.

The diagnostic value of determinations of the levels of chorionic gonadotropin (HCG) and trophoblastic beta 1-glycoprotein (TBG) was studied in 160 cases of trophoblastic disease. Trophoblastic disease was diagnosed in 86% of cases, when HCG level was determined immunologically and in 100 % -- by radioimmunological means and in 86 and 33% when TBG level was established by immunoradioautographical and immunodiffusion methods, respectively. The results of HCG and TBG assays by immunological and immunoradioautographical methods matched in 96% of cases. The said methods are highly specific and may find a wide application in diagnosing trophoblastic disease. The radioimmunological method of HCG assay is the most sensitive. However, in view of possible HCG synthesis in cases of other tumor, its application should be preferred in assessing the efficacy of therapy rather than for primary diagnosis of trophoblastic disease.