[The comparative pattern of neuromidin and magnetic stimulation influence on neuroplasticity in experimental traumatic neuropathy].

OBJECTIVE: Traumatic neuropathies are among the most actual problems in neurology due to the severe neurological deficit in most cases and poor prognosis of recovery. We evaluated the effect of ipidacrin (cholinesterase inhibitor) and magnetic stimulation on neuroplastic axonal changes after experimental neurotmesis of rat's sciatic nerve. MATERIAL AND METHODS: Animals (20 rats) were stratified into 3 groups. There was no treatment in the control group; in the second -group experimental animals underwent 3-5 min daily rhythmic magnetic stimulation (0,8-1T, 3 Hz) The third group of animals received intramuscular 0,035 mg of ipidacrin daily within 1 month. RESULTS AND CONCLUSIONS: Based on the received data on the restoration of myelin, axons, myelin nodes structure and lemmocyte ultrastructure), we have concluded that both magnetic stimulation and ipidacrin can trigger restorative and compensative processes in traumatic neuropathies.

[The сomparative analysis of neyromidin and cerebrolysin effects on neurodynamic processes during craniocerebral injury].

Effects of neyromidin and cerebrolysin on clinical and electrophysiological patterns of neurodynamic disorders during traumatic brain injury were studied. The study involved 50 patients, aged from 21 to 58 years, with mild craniocerebral injury in subacute period. Patients were stratified into two groups. Patients of the first group (n=25) were treated with the general drugs (vasoactive and nootropic preparations, vitamins) as well as with neyromidin in dosage of 15 mg intramuscularly 1 time a day during 10 days. The second group of patients (n=25) received both general treatment and 10 ml of cerebrolysin intravenously 1 time a day during 10 days. The whole investigation lasted for 20 days. Besides the standard neurological examination, the Hamilton anxiety rating scale (HARS), Multidimensional Fatigue Symptom Inventory-short form (MFSI-SH, general fatigue was assessed) and Kerdo index were administered. We have also evaluated somatosensory evoked potentials and performed magnetic diagnostics to calculate central motor conduction time. The analysis of the results suggests that the two investigated drugs have a beneficial effect on the neurodynamic disorders in case of the craniocerebral injury. Nevertheless, the impact of neyromidin was more apparent and valid throughout the whole study.