[Modern technologies for extraction of balneological medicines from mineral waters].

A new technology for isolation of medicinal balneological preparations from mineral waters has been developed. It is based on the extraction of biologically active compounds (BAC) from mineral waters with ethanol following oxidative hydrolysis and water vapour distillation. This technology has no analogs both in this country and abroad. Unlike ordinary balneological medicines, those obtained by the new method do not contain inorganic matrix, show higher activity, and remain stable for a longer period. The primary composition of BACs isolated by the above technology was studied using solid-phase extraction and chromatomass-spectrometry. Analysis of Extramine, a medicinal preparation from Novonukutskaya hydrogen sulfide mineral water (Siberian Matsesta), allowed to identify active components responsible for its therapeutic effects and elucidate mechanisms of their action. The 15-year-long experience with practical application of BACs obtained with the help of the new technology has demonstrated that they possesses antiallergic, antiviral, and analeptic activities. These compounds increase general resistance of the organism to infection, promote removal of toxic substances, accelerate wound and injury healing, and prevent the development of herpes infection.

[Comparative morphological characteristics of changes in the liver in case of poisoning with alcohol-containing liquids in human and following subacute treatment of animals with ethyl and propyl alcohols, ethylene glycol and their mixtures].

The authors present results of comparative morphological studies of changes in the liver after intoxication with alcohol-containing liquids in human and following subacute treatment of animals with ethyl and propyl alcohols, ethylene glycol and their mixtures. It was shown that poisoning caused by individual chemical substances and their mixtures induced significantly different changes in the liver of animals. The mixtures produced much more serious toxic lesions in the parenchymal tissue than individual spirits (including development of necrotization foci) and contributed to enhanced mortality of experimental animals. The morphological picture of the liver in human subjects poisoned by a mixture of alcohols resembled that after intoxication with carbon tetrachloride and was consistent with the changes in people who had died during episodes of mass poisoning with surrogate alcoholic beverages and alcohol-containing liquids.

[Effect of Novonukutskaya mineral water extracts on the clinical course of wound disease and wound healing in experiment].

The objective of the present work was to study the wound-healing potential of the new preparation, Extramin (a 32% ethanol extract of organic substances from Novonukutskaya mineral water) in a series of experiments on a model of chemical burns in rabbits. The wound healing process was monitored based on biochemical, hematiological, and morphological indicators. Analysis of the results allows for the conclusion that Extramin is a powerful stimulator of the wound-healing processes and can be recommended for further clinical studies.

[Hygienic standardization of fluogermanate in the air of a working area].

The paper presents the data on the impact of the most possible concentrations of fluogermanate (GeF4) in the air of a working area with a pencil-beam irritant acting the respiratory organs and those obtained from chronic experiments. The most possible concentration is 0.2 mg/m3 (Class II hazard).

[Hygienic standardization of the levels of selenium hexafluoride in the air of a working area]. / Gigienicheskoe normirovanie geksaftorida selena v vozdukhe rabochei zony.

The paper presents the results of investigations on the hygienic standardization of the levels of selenium hexafluoride (SeF6) in the air of a working area. It also analyzes the data on the effects of SeF6 inhalation on laboratory animals, by applying morphological, physiological, hematological, and biochemical studies. The studies have yielded the basic parameters of inhalation toxicity and established the threshold of the irritant action of the substance, developed and approved its maximally acceptable concentration (0.2 mg/m3, gas + vapors) and a procedure for photometric determination of SeF6 in the air of a working area.