[Sickle cell anemia (HBSS) in an adult patient from Tanzania]. / Serpovidnaia kletochnaia anemiia (HBSS) u vzroslogo bol'nogo iz Tanzanii.

There is a description of an observation of patient N., aged 29, (a student of Russian University for Peoples' Friendship and a citizen of Tanzania) suffering from sickle-cell anemia--SCA--(HbSS), homozygous type, which was detected at screening of abnormal Hb by electrophoresis on the cellulose acetate strips. The results of clinical-and-biological examinations of the patients are described. The patient had anemia (Hb 98-83 g/L); thrombotic (pain) crises with dark urination were periodically observed. HbS accounted for the bulwark (98%) of Hb, while small fractions of Hb (HbF and HbA2) were within the normal limits. This was a comparatively mild form of the disease; the patient had minor changes in the heart and lungs with other internal bodies being intact. Patient N. received, from childhood, an appropriate therapy including antibiotics, folic acid, analgesics etc. Obviously, this provides for an explanation to that he lived up to 29 years, withstood the acclimatization in Russia and could get education. A comparison of the clinical-and-laboratory indices of patient N. with the data of patients with SCA of other types (HbS-thalassemia, HbSC and HbSK) is presented.

[Early diagnosis and features of non-specific renal lesions in patients with pulmonary tuberculosis]. / Ranniaia diagnostika i osobennosti nespetsificheskogo porazheniia pochek bol'nykh teberkulëzom lëgkikh.

Two hundred and eight patients with pulmonary tuberculosis were examined. A risk for nonspecific renal disease was shown to be significantly higher in the presence of concomitant diseases, such as hypertensive and alcoholic disease, diabetes mellitus, and chronic pyelonephritis. The urinary low molecular-weight protein test was demonstrated to be of value in the early diagnosis of renal lesion and in the determination of its pattern. Long-term use of angiotensin-converting enzyme inhibitors was beneficial in patients with increased urinary albumin excretion. The spectrum of causative agents of urinary tract infection and their sensitivity to antibiotics were studied in patients with pulmonary tuberculosis. Fluoroquinolones were demonstrated to have some advantage in the treatment of these patients. The authors show it necessary to make a follow-up monitoring of renal function and an adequate therapeutical correction, which may retard the progression of renal abnormalities.

[Hemoglobinopathies in students at the Russian University of the Friendship of Peoples]. / Gemoglobinopatii u studentov Rossiuskogo universiteta druzhby narodov.

Screening of the university students for hemoglobinopathies detected 153 patients with various hemoglobin abnormalities; 69 with Hb AS, 3 with Hb S-beta-thalassemia, 4 with Hb S-alpha-thalassemia, 3 with hb SC, 1 with Hb SK, 1 with Hb CC, 38 with Hb AC, 1 with Hb A O Arab, 4 with Hb EE, 25 with Hb AE, 1 with Hb AD, 1 with Hb AI, 1 with beta-thalassemia major, and 1 with beta-thalassemia minor. The most grave disease was observed in a child with Hb S-beta-thalassemia and in a youth with beta-thalassemia major. The patterns of Hb SC disease varied. The majority of heterozygote carriers of Hb S, Hb C, Hb E, etc. were healthy. A total of 7000 students were screened by express electrophoresis on cellulose acetate films. more than 400 subjects with abnormal hemoglobins were detected, the most numerous of which were heterozygote carriers of Hb S (Hb AS).