RESUMO
This article describes ways of risk reducing of esophageal adenocarcinoma with the use of modern screening treatment methods of GERD and Barrett esophagus.
Assuntos
Esôfago de Barrett/diagnóstico , Esôfago de Barrett/tratamento farmacológico , Endoscopia do Sistema Digestório , Neoplasias Esofágicas/prevenção & controle , Inibidores da Bomba de Prótons/uso terapêutico , Esôfago de Barrett/complicações , Neoplasias Esofágicas/etiologia , Refluxo Gastroesofágico/complicações , Refluxo Gastroesofágico/diagnóstico , Refluxo Gastroesofágico/tratamento farmacológico , Antagonistas dos Receptores H2 da Histamina/administração & dosagem , Antagonistas dos Receptores H2 da Histamina/farmacocinética , Antagonistas dos Receptores H2 da Histamina/uso terapêutico , Humanos , Inibidores da Bomba de Prótons/administração & dosagem , Inibidores da Bomba de Prótons/farmacocinéticaAssuntos
Ácido Gástrico/metabolismo , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori/efeitos dos fármacos , Gastropatias/diagnóstico , Gastropatias/tratamento farmacológico , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Antiulcerosos/administração & dosagem , Antiulcerosos/uso terapêutico , Quimioterapia Combinada , Infecções por Helicobacter/etiologia , Infecções por Helicobacter/metabolismo , Humanos , Moscou , Inibidores da Bomba de Prótons/administração & dosagem , Inibidores da Bomba de Prótons/uso terapêutico , Federação Russa , Gastropatias/etiologia , Gastropatias/metabolismoAssuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Guias de Prática Clínica como Assunto , Úlcera Gástrica/diagnóstico , Úlcera Gástrica/terapia , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Feminino , Humanos , Masculino , Úlcera Gástrica/induzido quimicamente , Resultado do TratamentoRESUMO
Esomeprazole is efficient for acid-dependent diseases of the gastrointestinal tract in patients with chronic hepatitis and hepatic cirrhosis as it can reduce the disease symptoms and cause the epithelization of erosive and ulcerative defects of the mucous coat. The terms of the cicatrisation of erosive and ulcerative defects of the mucous coat of the esophagus, stomach and duodenum are comparable in patients with liver diseases and in the population (without chronic hepatic diseases). The simultaneous application of Nexium and modern hepatotropic drugs does not cause the development of hepatotoxic reactions.
Assuntos
Antiulcerosos/uso terapêutico , Esomeprazol/uso terapêutico , Hepatite Crônica/complicações , Cirrose Hepática/complicações , Úlcera Péptica/complicações , Úlcera Péptica/tratamento farmacológico , Adolescente , Adulto , Idoso , Antiulcerosos/efeitos adversos , Doença Crônica , Esomeprazol/efeitos adversos , Feminino , Ácido Gástrico/metabolismo , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The efficiency of treatment of patients with chronic hepatitis type C and liver cirrhosis of HCV etiology with PegIntron in conjunction with Ribavirin made up 73.3% in the group of patients with different HCV genotypes. Due to the development of side effects, it was possible to perform the complete course of treatment only in 30 patients out of 34 (88.2%). Side effects from the side of the central nervous system (irritability, depressive syndrome, sleep disorders), skin (xerodermia, alopecia, seborrhea), and weight loss prevailed against the background of combined treatment with PegIntron and Ribavirin. Upon the completion of treatment, side effects disappeared in 31 patients out of 34 (91.2%) within 1-3 months.
Assuntos
Antivirais/uso terapêutico , Infecções por HIV/complicações , Hepatite C Crônica/tratamento farmacológico , Interferon-alfa/uso terapêutico , Polietilenoglicóis , Ribavirina/uso terapêutico , Quimioterapia Combinada , Hepacivirus/genética , Hepatite C Crônica/complicações , Humanos , Interferon alfa-2 , Proteínas Recombinantes , Carga ViralRESUMO
The argument about advantages of certain herniotomy methods has not been settled up to now. Some authors believe that it is reasonable to perform a Shouldice's operation for all inguinal hernias, while others think that it is optimum to use synthetic materials. Certain surgeons prefer endoscopic techniques for recurrent inguinal hernias, etc. In all fairness, it should be acknowledged that none of the currently available hernioplasty methods can ultimately secure against a recurrence of hernia one hundred per cent. Only a differentiated approach to the selection of surgery methods, sufficient surgeon's experience in this field, thorough analysis of remote results of his own operations as well as the use of up-to-date plastic materials, all taken in the aggregate, can considerable improve the results of herniotomy.
Assuntos
Pancreatite/tratamento farmacológico , Adulto , Doença Crônica , Farmacoeconomia , Feminino , Fármacos Gastrointestinais/economia , Fármacos Gastrointestinais/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Pancreatite/economiaRESUMO
Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers. On day 14 of treatment ulcer healing was observed in 89.5% patients receiving intranasal Semax (1% solution, 2-4 drops 3 times a day for 10 days) vs. 30.8% in the control group. Clinical studies of antiulcer activity of Semax in different combinations with usual antiulcer drugs are needed.
Assuntos
Hormônio Adrenocorticotrópico/análogos & derivados , Hormônio Adrenocorticotrópico/uso terapêutico , Fármacos Neuroprotetores/uso terapêutico , Nootrópicos/uso terapêutico , Úlcera Péptica/tratamento farmacológico , Fragmentos de Peptídeos/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo , Resultado do TratamentoAssuntos
Anti-Infecciosos/uso terapêutico , Hepatopatias/tratamento farmacológico , Anti-Infecciosos/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico , Encefalopatia Hepática/tratamento farmacológico , Humanos , Cirrose Hepática/complicações , Peritonite/tratamento farmacológico , Peritonite/microbiologia , Peritonite/prevenção & controleAssuntos
Anti-Infecciosos/economia , Farmacoeconomia , Gastroenteropatias/economia , Infecções por Helicobacter/economia , Anti-Infecciosos/uso terapêutico , Custos e Análise de Custo , Gastroenteropatias/tratamento farmacológico , Gastroenteropatias/microbiologia , Infecções por Helicobacter/tratamento farmacológico , Humanos , Modelos EconômicosAssuntos
Úlcera Duodenal/tratamento farmacológico , Inibidores Enzimáticos/uso terapêutico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori/isolamento & purificação , Omeprazol/uso terapêutico , Adolescente , Adulto , Idoso , Antibacterianos , Quimioterapia Combinada/uso terapêutico , Úlcera Duodenal/classificação , Úlcera Duodenal/microbiologia , Feminino , Infecções por Helicobacter/classificação , Infecções por Helicobacter/microbiologia , Helicobacter pylori/classificação , Humanos , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Resultado do TratamentoAssuntos
Endorfinas/sangue , Doença Aguda , Úlcera Duodenal/sangue , Úlcera Duodenal/complicações , Etanol/efeitos adversos , Humanos , Infarto do Miocárdio/sangue , Infarto do Miocárdio/complicações , Pancreatite/sangue , Pancreatite/complicações , Síndrome de Abstinência a Substâncias/sangue , Síndrome de Abstinência a Substâncias/complicações , Fatores de Tempo , alfa-Endorfina , gama-EndorfinaRESUMO
Blood gamma-endorphin concentrations were repeatedly measured, using an original radioimmunoassay, in patients with myocardial infarction. In the early days of acute myocardial infarction, high levels of this opioid peptide were observed, then plasma gamma-endorphin concentration gradually decreased by the time of discharge. In patients with grave complications, gamma-endorphin level was significantly lower, as compared to patients with uncomplicated infarction.
Assuntos
Endorfinas/sangue , Infarto do Miocárdio/sangue , Adulto , Idoso , Endorfinas/antagonistas & inibidores , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/tratamento farmacológico , Propranolol/uso terapêutico , Fatores de Tempo , gama-EndorfinaRESUMO
Pharmacokinetics of dalargin, an opioid hexapeptide, was investigated on 7 males by two approaches. Dalargin radioimmunoassay was performed using a highly specific antiserum reacting only with the whole molecule. In radioreceptor assay lyophilized rat brain membranes containing opiate receptors were used. 2-6 min after intravenous introduction of 1-10 mg dalargin, immunoreactive dalargin blood concentration was lower than 0.5 ng/ml. The results of radioreceptor assay were presented as a biexponential curve with a fast main phase of activity changes (90%, characteristic time 1.5-5.0 min) and a slow "clearance" phase (10% of the substance, characteristic time 85-200 min). Prolonged presence of receptor-active substances in the blood can be attributed to the products of dalargin degeneration, namely its N-terminal penta- and tetrapeptides.
Assuntos
Leucina Encefalina-2-Alanina/análogos & derivados , Encefalina Leucina/análogos & derivados , Adulto , Encefalina Leucina/sangue , Humanos , Cinética , Masculino , Pessoa de Meia-Idade , Radioimunoensaio , Ensaio RadioliganteRESUMO
Physiotherapeutic and other methods were employed for the treatment of patients with chronic nonobstructive bronchitis (CNB), chronic bronchitis with transient obstruction of the small bronchi of inflammatory genesis, chronic asthmatic bronchitis (CAB) and chronic obstructive bronchitis (COB). The level of secretory IgA and relative E-RFC number in the bronchial wash off, lysozyme concentration, the level of IgA and titer of heterophilic normal antibodies in the saliva were assessed. The content of T- and B-lymphocytes in the blood was studied. The results were assessed with a method of discrete-dynamic analysis. It was established that the incorporation of inductothermia with ethonium-electrophoresis and the magnetic field effect on the thyroid in CAB and inductothermia with ethonium-electrophoresis in COB in the complex of therapeutic measures produced a positive effect. In CNB (inactive phase) and COB patients inductothermia resulted in restoration of some interrelationships in the immune system whereas in CAB patients in their dysbalance. Different changes in the levels of interrelationships of certain parameters of the immune system were observed in the incorporation of sinusoidal modulated currents in the therapeutic complexes.
Assuntos
Anticorpos Antibacterianos/análise , Linfócitos B/imunologia , Bronquite/imunologia , Imunoglobulinas/análise , Infecções Estafilocócicas/imunologia , Staphylococcus/imunologia , Linfócitos T/imunologia , Adulto , Bronquite/terapia , Doença Crônica , Terapia Combinada , Terapia por Estimulação Elétrica/métodos , Feminino , Humanos , Imunoglobulina E/análise , Imunoglobulina G/análise , Contagem de Leucócitos , Magnetoterapia , Masculino , Pessoa de Meia-Idade , Compostos de Amônio Quaternário/administração & dosagem , Formação de RosetaRESUMO
The authors describe the results of studying basal gastrin secretion in patients with peptic ulcer of the duodenum at different phases of disease treated in 3 stages. It was revealed that basal secretion of gastrin experienced substantial changes in the course of transition from the phase of exacerbation to the phase of disease remission. It was noted that the onset of the clinico-endoscopic remission of peptic ulcer did not correlate in all the cases with normalization of basal gastrin level. Patients who did not show normalization of basal gastrin level during treatment were more prone to the development of repeated exacerbations. Based on the data obtained the authors determined the prognostic importance of radioimmunoassay of gastrin basal concentration over time. The increment of gastrin concentration by more than 35 pg/ml of the level seen during peptic ulcer exacerbation is a prognostically unfavourable sign, for the probability of relapses rises up to 79% during a year.